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• W1971810562 abstract "It has been shown that matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of various pulmonary inflammatory diseases. We determined the MMP-9 concentration in the plasma of community-acquired pneumonia (CAP) patients before and after antibiotic treatment.Gelatin zymography and ELISA analysis were used to measure MMP-9 activity and MMP-9 level, respectively, in 35 control subjects and 46 CAP patients.WBC counts, neutrophils, MMP-9 activity and MMP-9 level were significantly higher in CAP patients compared with that of control subjects (P<0.001), while MMP-9 activity and MMP-9 level were returned to normal after the antibiotic treatment (P<0.001). In addition, MMP-9 level correlated positively with WBC counts and neutrophils number both before and after the antibiotic treatment.MMP-9 may play an important role in the pathogenesis of CAP with a positive correlation with the number of neutrophils." @default.
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• W1971810562 date "2005-02-01" @default.
• W1971810562 modified "2023-09-26" @default.
• W1971810562 title "Excessive matrix metalloproteinase-9 in the plasma of community-acquired pneumonia" @default.
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• W1971810562 doi "https://doi.org/10.1016/j.cccn.2004.09.025" @default.
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