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- W1971816874 abstract "The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer." @default.
- W1971816874 created "2016-06-24" @default.
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- W1971816874 date "2007-02-01" @default.
- W1971816874 modified "2023-10-17" @default.
- W1971816874 title "Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer" @default.
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- W1971816874 doi "https://doi.org/10.1016/j.canlet.2006.03.014" @default.
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