FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971832222> ?p ?o ?g. }

• W1971832222 endingPage "2127" @default.
• W1971832222 startingPage "2121" @default.
• W1971832222 abstract "Vascular endothelial growth factor (VEGF)‐D induces lymphangiogenesis by activating VEGF receptor (VEGFR)‐3, which is expressed mainly by lymphatic endothelial cells. VEGFR‐3 has also been detected in several types of malignant cells, but the significance of VEGFR‐3 expression by malignant cells remains unclear. We examined the expression and function of VEGF‐D/VEGFR‐3 in human gastric carcinoma cells. Expression of VEGF‐D and VEGFR‐3 was analyzed in three human gastric carcinoma cell lines and 29 surgical specimens. cDNA microarray analysis was used to examine the effect of VEGF‐D on the expression of genes associated with disease progression in VEGFR‐3‐expressing KKLS cells. VEGF‐D‐transfected cells and control cells were transplanted into the gastric wall of nude mice. In 10 of the 29 (34%) gastric carcinoma specimens and two of the three cell lines, cancer cells expressed both VEGF‐D and VEGFR‐3. In vitro treatment of KKLS cells with exogenous VEGF‐D increased expression of cyclin D1 and Bcl‐2 and stimulated cell proliferation. VEGF‐D transfection into KKLS cells resulted in stimulation of angiogenesis, lymphangiogenesis, and cell proliferation, and in inhibition of apoptosis. VEGF‐D may participate in the progression of human gastric carcinoma by acting via autocrine and paracrine mechanisms. ( Cancer Sci 2010)" @default.
• W1971832222 created "2016-06-24" @default.
• W1971832222 creator A5023958825 @default.
• W1971832222 creator A5024171576 @default.
• W1971832222 creator A5030909676 @default.
• W1971832222 creator A5043200769 @default.
• W1971832222 creator A5046204028 @default.
• W1971832222 creator A5046639249 @default.
• W1971832222 creator A5048558405 @default.
• W1971832222 creator A5075486346 @default.
• W1971832222 creator A5086850753 @default.
• W1971832222 date "2010-06-17" @default.
• W1971832222 modified "2023-10-17" @default.
• W1971832222 title "Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells" @default.
• W1971832222 cites W1489873347 @default.
• W1971832222 cites W1820344370 @default.
• W1971832222 cites W1974097718 @default.
• W1971832222 cites W1982246723 @default.
• W1971832222 cites W1991958278 @default.
• W1971832222 cites W1996706763 @default.
• W1971832222 cites W1999223106 @default.
• W1971832222 cites W2000375890 @default.
• W1971832222 cites W2001658518 @default.
• W1971832222 cites W2003450086 @default.
• W1971832222 cites W2009968499 @default.
• W1971832222 cites W2025474713 @default.
• W1971832222 cites W2025933554 @default.
• W1971832222 cites W2038601735 @default.
• W1971832222 cites W2039114719 @default.
• W1971832222 cites W2043711546 @default.
• W1971832222 cites W2046054013 @default.
• W1971832222 cites W2049424656 @default.
• W1971832222 cites W2050888224 @default.
• W1971832222 cites W2069225985 @default.
• W1971832222 cites W2074639980 @default.
• W1971832222 cites W2084255175 @default.
• W1971832222 cites W2084844081 @default.
• W1971832222 cites W2101425659 @default.
• W1971832222 cites W2117452881 @default.
• W1971832222 cites W2118282739 @default.
• W1971832222 cites W2126156135 @default.
• W1971832222 cites W2149304811 @default.
• W1971832222 cites W2155591311 @default.
• W1971832222 cites W2159241628 @default.
• W1971832222 cites W2164738538 @default.
• W1971832222 cites W2319962899 @default.
• W1971832222 doi "https://doi.org/10.1111/j.1349-7006.2010.01649.x" @default.
• W1971832222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20626397" @default.
• W1971832222 hasPublicationYear "2010" @default.
• W1971832222 type Work @default.
• W1971832222 sameAs 1971832222 @default.
• W1971832222 citedByCount "10" @default.
• W1971832222 countsByYear W19718322222012 @default.
• W1971832222 countsByYear W19718322222015 @default.
• W1971832222 countsByYear W19718322222018 @default.
• W1971832222 countsByYear W19718322222019 @default.
• W1971832222 countsByYear W19718322222020 @default.
• W1971832222 crossrefType "journal-article" @default.
• W1971832222 hasAuthorship W1971832222A5023958825 @default.
• W1971832222 hasAuthorship W1971832222A5024171576 @default.
• W1971832222 hasAuthorship W1971832222A5030909676 @default.
• W1971832222 hasAuthorship W1971832222A5043200769 @default.
• W1971832222 hasAuthorship W1971832222A5046204028 @default.
• W1971832222 hasAuthorship W1971832222A5046639249 @default.
• W1971832222 hasAuthorship W1971832222A5048558405 @default.
• W1971832222 hasAuthorship W1971832222A5075486346 @default.
• W1971832222 hasAuthorship W1971832222A5086850753 @default.
• W1971832222 hasBestOaLocation W19718322221 @default.
• W1971832222 hasConcept C103041312 @default.
• W1971832222 hasConcept C121608353 @default.
• W1971832222 hasConcept C126322002 @default.
• W1971832222 hasConcept C128240485 @default.
• W1971832222 hasConcept C146285616 @default.
• W1971832222 hasConcept C167734588 @default.
• W1971832222 hasConcept C170493617 @default.
• W1971832222 hasConcept C2776636583 @default.
• W1971832222 hasConcept C2777025900 @default.
• W1971832222 hasConcept C2779013556 @default.
• W1971832222 hasConcept C2780394083 @default.
• W1971832222 hasConcept C502942594 @default.
• W1971832222 hasConcept C54009773 @default.
• W1971832222 hasConcept C54355233 @default.
• W1971832222 hasConcept C71924100 @default.
• W1971832222 hasConcept C7876069 @default.
• W1971832222 hasConcept C81885089 @default.
• W1971832222 hasConcept C86803240 @default.
• W1971832222 hasConcept C96232424 @default.
• W1971832222 hasConceptScore W1971832222C103041312 @default.
• W1971832222 hasConceptScore W1971832222C121608353 @default.
• W1971832222 hasConceptScore W1971832222C126322002 @default.
• W1971832222 hasConceptScore W1971832222C128240485 @default.
• W1971832222 hasConceptScore W1971832222C146285616 @default.
• W1971832222 hasConceptScore W1971832222C167734588 @default.
• W1971832222 hasConceptScore W1971832222C170493617 @default.
• W1971832222 hasConceptScore W1971832222C2776636583 @default.
• W1971832222 hasConceptScore W1971832222C2777025900 @default.
• W1971832222 hasConceptScore W1971832222C2779013556 @default.
• W1971832222 hasConceptScore W1971832222C2780394083 @default.

• next