FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971832964> ?p ?o ?g. }

• W1971832964 endingPage "4284" @default.
• W1971832964 startingPage "4276" @default.
• W1971832964 abstract "The rpoS gene codes for an alternative RNA polymerase sigma factor, which acts as a general regulator of the stress response. Inactivating alleles of rpoS in collections of natural Escherichia coli isolates have been observed at very variable frequencies, from less than 1% to more than 70% of strains. rpoS is easily inactivated in nutrient-deprived environments such as stab storage, which makes it difficult to determine the true frequency of rpoS inactivation in nature. We studied the evolutionary history of rpoS and compared it to the phylogenetic history of bacteria in two collections of 82 human commensal and extraintestinal E. coli strains. These strains were representative of the phylogenetic diversity of the species and differed only by their storage conditions. In both collections, the phylogenetic histories of rpoS and of the strains were congruent, indicating that horizontal gene transfer had not occurred at the rpoS locus, and rpoS was under strong purifying selection, with a ratio of the nonsynonymous mutation rate (Ka) to the synonymous substitution rate (Ks) substantially smaller than 1. Stab storage was associated with a high frequency of inactivating alleles, whereas almost no amino acid sequence variation was observed in RpoS in the collection studied directly after isolation of the strains from the host. Furthermore, the accumulation of variations in rpoS was typical of source-sink dynamics. In conclusion, rpoS is rarely inactivated in natural E. coli isolates within their mammalian hosts, probably because such strains rapidly become evolutionary dead ends. Our data should encourage bacteriologists to freeze isolates immediately and to avoid the use of stab storage." @default.
• W1971832964 created "2016-06-24" @default.
• W1971832964 creator A5014395806 @default.
• W1971832964 creator A5018025533 @default.
• W1971832964 creator A5018390315 @default.
• W1971832964 creator A5046289689 @default.
• W1971832964 creator A5058376625 @default.
• W1971832964 creator A5076790914 @default.
• W1971832964 creator A5079264989 @default.
• W1971832964 date "2014-12-15" @default.
• W1971832964 modified "2023-10-14" @default.
• W1971832964 title "The <i>rpoS</i> Gene Is Predominantly Inactivated during Laboratory Storage and Undergoes Source-Sink Evolution in Escherichia coli Species" @default.
• W1971832964 cites W1556215826 @default.
• W1971832964 cites W1610171770 @default.
• W1971832964 cites W1882626221 @default.
• W1971832964 cites W1967014582 @default.
• W1971832964 cites W1968727156 @default.
• W1971832964 cites W1969765938 @default.
• W1971832964 cites W1978953588 @default.
• W1971832964 cites W1980310800 @default.
• W1971832964 cites W1988772211 @default.
• W1971832964 cites W1997254726 @default.
• W1971832964 cites W1997771398 @default.
• W1971832964 cites W2002829084 @default.
• W1971832964 cites W2003062832 @default.
• W1971832964 cites W2005279764 @default.
• W1971832964 cites W2006309168 @default.
• W1971832964 cites W2024937746 @default.
• W1971832964 cites W2025445241 @default.
• W1971832964 cites W2037654903 @default.
• W1971832964 cites W2046008552 @default.
• W1971832964 cites W2047394015 @default.
• W1971832964 cites W2049433285 @default.
• W1971832964 cites W2050976530 @default.
• W1971832964 cites W2051116946 @default.
• W1971832964 cites W2053670382 @default.
• W1971832964 cites W2063199570 @default.
• W1971832964 cites W2065172786 @default.
• W1971832964 cites W2070208126 @default.
• W1971832964 cites W2070747934 @default.
• W1971832964 cites W2074203599 @default.
• W1971832964 cites W2075716499 @default.
• W1971832964 cites W2077833308 @default.
• W1971832964 cites W2082692364 @default.
• W1971832964 cites W2082711139 @default.
• W1971832964 cites W2095769280 @default.
• W1971832964 cites W2096647574 @default.
• W1971832964 cites W2097005840 @default.
• W1971832964 cites W2097734621 @default.
• W1971832964 cites W2100580791 @default.
• W1971832964 cites W2102306849 @default.
• W1971832964 cites W2104384253 @default.
• W1971832964 cites W2106814707 @default.
• W1971832964 cites W2116672989 @default.
• W1971832964 cites W2118497545 @default.
• W1971832964 cites W2118711915 @default.
• W1971832964 cites W2122700446 @default.
• W1971832964 cites W2125201618 @default.
• W1971832964 cites W2127444840 @default.
• W1971832964 cites W2129172649 @default.
• W1971832964 cites W2137574609 @default.
• W1971832964 cites W2138725893 @default.
• W1971832964 cites W2139327515 @default.
• W1971832964 cites W2139832617 @default.
• W1971832964 cites W2139852129 @default.
• W1971832964 cites W2140818602 @default.
• W1971832964 cites W2141125686 @default.
• W1971832964 cites W2142402047 @default.
• W1971832964 cites W2142583587 @default.
• W1971832964 cites W2143888114 @default.
• W1971832964 cites W2147189207 @default.
• W1971832964 cites W2153303237 @default.
• W1971832964 cites W2155281470 @default.
• W1971832964 cites W2158408911 @default.
• W1971832964 cites W2166160777 @default.
• W1971832964 doi "https://doi.org/10.1128/jb.01972-14" @default.
• W1971832964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4248845" @default.
• W1971832964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25266386" @default.
• W1971832964 hasPublicationYear "2014" @default.
• W1971832964 type Work @default.
• W1971832964 sameAs 1971832964 @default.
• W1971832964 citedByCount "36" @default.
• W1971832964 countsByYear W19718329642016 @default.
• W1971832964 countsByYear W19718329642017 @default.
• W1971832964 countsByYear W19718329642018 @default.
• W1971832964 countsByYear W19718329642019 @default.
• W1971832964 countsByYear W19718329642020 @default.
• W1971832964 countsByYear W19718329642021 @default.
• W1971832964 countsByYear W19718329642022 @default.
• W1971832964 countsByYear W19718329642023 @default.
• W1971832964 crossrefType "journal-article" @default.
• W1971832964 hasAuthorship W1971832964A5014395806 @default.
• W1971832964 hasAuthorship W1971832964A5018025533 @default.
• W1971832964 hasAuthorship W1971832964A5018390315 @default.
• W1971832964 hasAuthorship W1971832964A5046289689 @default.
• W1971832964 hasAuthorship W1971832964A5058376625 @default.
• W1971832964 hasAuthorship W1971832964A5076790914 @default.
• W1971832964 hasAuthorship W1971832964A5079264989 @default.

• next