FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971838118> ?p ?o ?g. }

• W1971838118 endingPage "391" @default.
• W1971838118 startingPage "383" @default.
• W1971838118 abstract "Smooth muscle cells in arteries of diabetic rats and rabbits have unique properties including the overexpression of platelet-derived growth factor (PDGF) beta-receptor compared with controls. Fibronectin, one of the increased components of extra-cellular matrices in diabetic arteries, plays an important role in the phenotypic change of smooth muscle cells from the contractile to the synthetic type with the expression of the PDGF beta-receptor. Moreover, fibronectin synthesis is regulated by transforming growth factor-beta (TGF-beta). In this study, we report on the expression of TGF-beta receptors in diabetic smooth muscle cells, by immunohistochemistry, cross-linking of 125I-TGF-beta 1 to cells and quantitative reverse transcription-polymerase chain reaction. We also report on the effects of TGF-beta 1 on fibronectin synthesis of diabetic smooth muscle cells by use of ELISA and immunoprecipitation, in order to clarify the role of TGF-beta-fibronectin pathway in forming characteristic changes of diabetic smooth muscle cells. Cultured aortic smooth muscle cells of diabetic rats expressed TGF-beta type II receptor about 8.7 times that of controls at the protein level and 5.7 times at the mRNA level, whereas the expression of the type I receptor did not differ between the two types of smooth muscle cells. These changes were accompanied by increased fibronectin synthesis in diabetic smooth muscle cells in response to TGF-beta 1. Furthermore, protein expression of fibronectin, and mRNA and protein of TGF-beta type II receptor were increased in the diabetic aorta compared with the control aorta in vivo, implying the importance of the TGF-beta-fibronectin pathway for the unique biology of smooth muscle cells in the diabetic artery." @default.
• W1971838118 created "2016-06-24" @default.
• W1971838118 creator A5003742850 @default.
• W1971838118 creator A5009610726 @default.
• W1971838118 creator A5014645524 @default.
• W1971838118 creator A5015653661 @default.
• W1971838118 creator A5066156587 @default.
• W1971838118 date "1997-03-20" @default.
• W1971838118 modified "2023-09-26" @default.
• W1971838118 title "Transforming growth factor-β receptor and fibronectin expressions in aortic smooth muscle cells in diabetic rats" @default.
• W1971838118 cites W1505978562 @default.
• W1971838118 cites W1529983307 @default.
• W1971838118 cites W1577282104 @default.
• W1971838118 cites W1889244777 @default.
• W1971838118 cites W1967850071 @default.
• W1971838118 cites W1968538228 @default.
• W1971838118 cites W1990205754 @default.
• W1971838118 cites W1992242015 @default.
• W1971838118 cites W1997501819 @default.
• W1971838118 cites W1997582444 @default.
• W1971838118 cites W2003918448 @default.
• W1971838118 cites W2014776502 @default.
• W1971838118 cites W2015216741 @default.
• W1971838118 cites W2017072501 @default.
• W1971838118 cites W2053984681 @default.
• W1971838118 cites W2055188605 @default.
• W1971838118 cites W2058354015 @default.
• W1971838118 cites W2072941419 @default.
• W1971838118 cites W2103484049 @default.
• W1971838118 cites W2115393190 @default.
• W1971838118 cites W2169863019 @default.
• W1971838118 cites W2431495653 @default.
• W1971838118 cites W97468714 @default.
• W1971838118 cites W2123220577 @default.
• W1971838118 doi "https://doi.org/10.1007/s001250050691" @default.
• W1971838118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9112014" @default.
• W1971838118 hasPublicationYear "1997" @default.
• W1971838118 type Work @default.
• W1971838118 sameAs 1971838118 @default.
• W1971838118 citedByCount "29" @default.
• W1971838118 countsByYear W19718381182014 @default.
• W1971838118 countsByYear W19718381182016 @default.
• W1971838118 countsByYear W19718381182018 @default.
• W1971838118 countsByYear W19718381182021 @default.
• W1971838118 countsByYear W19718381182022 @default.
• W1971838118 crossrefType "journal-article" @default.
• W1971838118 hasAuthorship W1971838118A5003742850 @default.
• W1971838118 hasAuthorship W1971838118A5009610726 @default.
• W1971838118 hasAuthorship W1971838118A5014645524 @default.
• W1971838118 hasAuthorship W1971838118A5015653661 @default.
• W1971838118 hasAuthorship W1971838118A5066156587 @default.
• W1971838118 hasBestOaLocation W19718381181 @default.
• W1971838118 hasConcept C118131993 @default.
• W1971838118 hasConcept C126322002 @default.
• W1971838118 hasConcept C134018914 @default.
• W1971838118 hasConcept C170493617 @default.
• W1971838118 hasConcept C180361614 @default.
• W1971838118 hasConcept C189165786 @default.
• W1971838118 hasConcept C2775960820 @default.
• W1971838118 hasConcept C2778229498 @default.
• W1971838118 hasConcept C2779395532 @default.
• W1971838118 hasConcept C2781294074 @default.
• W1971838118 hasConcept C2992686903 @default.
• W1971838118 hasConcept C71924100 @default.
• W1971838118 hasConcept C86492073 @default.
• W1971838118 hasConcept C86803240 @default.
• W1971838118 hasConcept C95444343 @default.
• W1971838118 hasConceptScore W1971838118C118131993 @default.
• W1971838118 hasConceptScore W1971838118C126322002 @default.
• W1971838118 hasConceptScore W1971838118C134018914 @default.
• W1971838118 hasConceptScore W1971838118C170493617 @default.
• W1971838118 hasConceptScore W1971838118C180361614 @default.
• W1971838118 hasConceptScore W1971838118C189165786 @default.
• W1971838118 hasConceptScore W1971838118C2775960820 @default.
• W1971838118 hasConceptScore W1971838118C2778229498 @default.
• W1971838118 hasConceptScore W1971838118C2779395532 @default.
• W1971838118 hasConceptScore W1971838118C2781294074 @default.
• W1971838118 hasConceptScore W1971838118C2992686903 @default.
• W1971838118 hasConceptScore W1971838118C71924100 @default.
• W1971838118 hasConceptScore W1971838118C86492073 @default.
• W1971838118 hasConceptScore W1971838118C86803240 @default.
• W1971838118 hasConceptScore W1971838118C95444343 @default.
• W1971838118 hasIssue "4" @default.
• W1971838118 hasLocation W19718381181 @default.
• W1971838118 hasLocation W19718381182 @default.
• W1971838118 hasOpenAccess W1971838118 @default.
• W1971838118 hasPrimaryLocation W19718381181 @default.
• W1971838118 hasRelatedWork W2002796681 @default.
• W1971838118 hasRelatedWork W2008091740 @default.
• W1971838118 hasRelatedWork W2064061791 @default.
• W1971838118 hasRelatedWork W2076014090 @default.
• W1971838118 hasRelatedWork W2102049381 @default.
• W1971838118 hasRelatedWork W2150615178 @default.
• W1971838118 hasRelatedWork W2168791530 @default.
• W1971838118 hasRelatedWork W2412296850 @default.
• W1971838118 hasRelatedWork W2417443534 @default.
• W1971838118 hasRelatedWork W2469155503 @default.
• W1971838118 hasVolume "40" @default.

• next