FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971840805> ?p ?o ?g. }

• W1971840805 endingPage "934" @default.
• W1971840805 startingPage "925" @default.
• W1971840805 abstract "OBJECTIVE: We evaluated local and systemic pharmacokinetics and pharmacodynamics of sirolimus-eluting stents (SES) in canine cerebral vessels. METHODS: SES (1.5 × 8 mm, 79 μg/479 μg sirolimus) and control stents (1.5 × 8 mm stainless steel with or without polymer) were implanted in canine basilar and ventral spinal arteries. Animals were sacrificed for local pharmacokinetic (36 animals at 1, 3, 8, 30, 90, 180 days) and pharmacodynamic (60 animals at 3, 30, 90, 180 days) assessment. RESULTS: Postrecovery adverse clinical events were not serious, requiring no unscheduled treatment. Histologically, brain and spinal cord sections revealed scattered microinfarcts and minimal gliosis consistent with postprocedure changes in all four stent-treatment groups. All stented vessels at all time points demonstrated good luminal patency with low injury and inflammation scores and no thrombosis of either stented or branch arteries. Endothelialization was complete in all stent groups by 30 days. Intimal smooth muscle cell scores were reduced in both SES groups at 30, 90, and 180 days. Systemic sirolimus levels peaked between 1 and 7 hours postimplant (maximum concentration, 1.2 ± 1.47, 79 μg; 4.5 ± 1.23 ng/ml, 479 μg), then declined rapidly to 1 ng/ml or less by 96 hours. Peak local tissue sirolimus levels were 41.5 ng/mg (79 μg) and 65 ng/mg (479 μg). CONCLUSION: SES in canine cerebral vessels were associated with good luminal patency to 180 days, with complete endothelialization and no evidence of acute thrombosis. This model has shown that SES deployed within the brain do not cause neurotoxicity during a 180-day time course, even when exaggerated doses are used. The findings support the contention that SES are safe to use and maintain patency in cerebral vessels." @default.
• W1971840805 created "2016-06-24" @default.
• W1971840805 creator A5000662950 @default.
• W1971840805 creator A5013989394 @default.
• W1971840805 creator A5014450486 @default.
• W1971840805 creator A5025503652 @default.
• W1971840805 creator A5028101627 @default.
• W1971840805 creator A5052383737 @default.
• W1971840805 creator A5065150386 @default.
• W1971840805 creator A5065425877 @default.
• W1971840805 creator A5071971143 @default.
• W1971840805 creator A5088015440 @default.
• W1971840805 date "2006-10-01" @default.
• W1971840805 modified "2023-09-24" @default.
• W1971840805 title "Safety and Pharmacokinetics of Sirolimus-eluting Stents in the Canine Cerebral Vasculature: 180 Day Assessment" @default.
• W1971840805 cites W1858061569 @default.
• W1971840805 cites W1964411834 @default.
• W1971840805 cites W1974046965 @default.
• W1971840805 cites W1980205676 @default.
• W1971840805 cites W1988461329 @default.
• W1971840805 cites W1998004031 @default.
• W1971840805 cites W2004556881 @default.
• W1971840805 cites W2015666576 @default.
• W1971840805 cites W2019918320 @default.
• W1971840805 cites W2022793713 @default.
• W1971840805 cites W2053467994 @default.
• W1971840805 cites W2070737716 @default.
• W1971840805 cites W2074324015 @default.
• W1971840805 cites W2079818105 @default.
• W1971840805 cites W2088549042 @default.
• W1971840805 cites W2092689878 @default.
• W1971840805 cites W2092964229 @default.
• W1971840805 cites W2102358305 @default.
• W1971840805 cites W2104337019 @default.
• W1971840805 cites W2105967935 @default.
• W1971840805 cites W2109093206 @default.
• W1971840805 cites W2117378826 @default.
• W1971840805 cites W2120184960 @default.
• W1971840805 cites W2121718174 @default.
• W1971840805 cites W2130331871 @default.
• W1971840805 cites W2138240704 @default.
• W1971840805 cites W2145565928 @default.
• W1971840805 cites W2158147889 @default.
• W1971840805 cites W2165771298 @default.
• W1971840805 cites W2168139815 @default.
• W1971840805 cites W2171098366 @default.
• W1971840805 cites W2413870938 @default.
• W1971840805 cites W3145965715 @default.
• W1971840805 cites W4206187417 @default.
• W1971840805 doi "https://doi.org/10.1227/01.neu.0000233777.46522.1e" @default.
• W1971840805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17038957" @default.
• W1971840805 hasPublicationYear "2006" @default.
• W1971840805 type Work @default.
• W1971840805 sameAs 1971840805 @default.
• W1971840805 citedByCount "18" @default.
• W1971840805 countsByYear W19718408052012 @default.
• W1971840805 countsByYear W19718408052014 @default.
• W1971840805 countsByYear W19718408052017 @default.
• W1971840805 countsByYear W19718408052020 @default.
• W1971840805 countsByYear W19718408052022 @default.
• W1971840805 countsByYear W19718408052023 @default.
• W1971840805 crossrefType "journal-article" @default.
• W1971840805 hasAuthorship W1971840805A5000662950 @default.
• W1971840805 hasAuthorship W1971840805A5013989394 @default.
• W1971840805 hasAuthorship W1971840805A5014450486 @default.
• W1971840805 hasAuthorship W1971840805A5025503652 @default.
• W1971840805 hasAuthorship W1971840805A5028101627 @default.
• W1971840805 hasAuthorship W1971840805A5052383737 @default.
• W1971840805 hasAuthorship W1971840805A5065150386 @default.
• W1971840805 hasAuthorship W1971840805A5065425877 @default.
• W1971840805 hasAuthorship W1971840805A5071971143 @default.
• W1971840805 hasAuthorship W1971840805A5088015440 @default.
• W1971840805 hasBestOaLocation W19718408051 @default.
• W1971840805 hasConcept C111113717 @default.
• W1971840805 hasConcept C112705442 @default.
• W1971840805 hasConcept C126322002 @default.
• W1971840805 hasConcept C126894567 @default.
• W1971840805 hasConcept C141071460 @default.
• W1971840805 hasConcept C2777921159 @default.
• W1971840805 hasConcept C2778583881 @default.
• W1971840805 hasConcept C2780868729 @default.
• W1971840805 hasConcept C42219234 @default.
• W1971840805 hasConcept C71924100 @default.
• W1971840805 hasConceptScore W1971840805C111113717 @default.
• W1971840805 hasConceptScore W1971840805C112705442 @default.
• W1971840805 hasConceptScore W1971840805C126322002 @default.
• W1971840805 hasConceptScore W1971840805C126894567 @default.
• W1971840805 hasConceptScore W1971840805C141071460 @default.
• W1971840805 hasConceptScore W1971840805C2777921159 @default.
• W1971840805 hasConceptScore W1971840805C2778583881 @default.
• W1971840805 hasConceptScore W1971840805C2780868729 @default.
• W1971840805 hasConceptScore W1971840805C42219234 @default.
• W1971840805 hasConceptScore W1971840805C71924100 @default.
• W1971840805 hasIssue "4" @default.
• W1971840805 hasLocation W19718408051 @default.
• W1971840805 hasLocation W19718408052 @default.
• W1971840805 hasOpenAccess W1971840805 @default.
• W1971840805 hasPrimaryLocation W19718408051 @default.

• next