FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971856495> ?p ?o ?g. }

• W1971856495 endingPage "349" @default.
• W1971856495 startingPage "339" @default.
• W1971856495 abstract "Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, and a desensitization of PKC to cholinergic input which were highly correlated with the behavioral performance and were reversed by cholinergic grafting. Therefore, we studied the receptor induced activation of the behaviorally relevant PKCgamma and PKCbetaII isoforms and the less behaviorally relevant PKCalpha isoform. Time course studies revealed peak translocation after 40 min incubation with carbachol for PKCgamma (110% increase from basal, i.e. no carbachol level, P < 0.01), 30 min for phosphorylated PKCbetaII (130%, P < 0.05) and 5 min for non-phosphorylated PKCbetaII (64%, P < 0.05) with no peak for alpha. Prenatal heroin abolished the translocation of PKCgamma and PKCbetaII while PKCalpha remained unaffected. A decrease occurred in basal phosphorylated membrane (-45%, P < 0.01) and cytosol-associated (-29%, P < 0.01) PKCbetaII, in membrane-associated non-phosphorylated PKCbetaII (-32%, P < 0.01) and PKCgamma (-25%, P < 0.01) and in cytosolic PKCalpha (-27%, P < 0.01), while membrane-associated PKCalpha was slightly increased (11%, P < 0.05). The results suggest that prenatal heroin disrupts cholinergic receptor induced PKC translocation and activation with the underlying mechanism of neuroteratogenicity potentially lying in the PKCgamma and PKCbetaII, while PKCalpha remains unaffected." @default.
• W1971856495 created "2016-06-24" @default.
• W1971856495 creator A5052999091 @default.
• W1971856495 creator A5079146016 @default.
• W1971856495 creator A5089423495 @default.
• W1971856495 date "2004-05-01" @default.
• W1971856495 modified "2023-10-09" @default.
• W1971856495 title "Prenatal heroin exposure alters cholinergic receptor stimulated activation of the PKCβII and PKCγ isoforms" @default.
• W1971856495 cites W1555886595 @default.
• W1971856495 cites W1660095449 @default.
• W1971856495 cites W1874938414 @default.
• W1971856495 cites W1970041992 @default.
• W1971856495 cites W1971183078 @default.
• W1971856495 cites W1971695868 @default.
• W1971856495 cites W1971914621 @default.
• W1971856495 cites W1979420700 @default.
• W1971856495 cites W1980641807 @default.
• W1971856495 cites W1990591017 @default.
• W1971856495 cites W1991859080 @default.
• W1971856495 cites W1993968078 @default.
• W1971856495 cites W2000002640 @default.
• W1971856495 cites W2003262023 @default.
• W1971856495 cites W2005822178 @default.
• W1971856495 cites W2009565492 @default.
• W1971856495 cites W2011983774 @default.
• W1971856495 cites W2012311232 @default.
• W1971856495 cites W2018777428 @default.
• W1971856495 cites W2020869636 @default.
• W1971856495 cites W2025122498 @default.
• W1971856495 cites W2026095028 @default.
• W1971856495 cites W2027650340 @default.
• W1971856495 cites W2027936784 @default.
• W1971856495 cites W2029872814 @default.
• W1971856495 cites W2032573956 @default.
• W1971856495 cites W2032731735 @default.
• W1971856495 cites W2032891869 @default.
• W1971856495 cites W2033785444 @default.
• W1971856495 cites W2034263343 @default.
• W1971856495 cites W2040380855 @default.
• W1971856495 cites W2041871219 @default.
• W1971856495 cites W2045357395 @default.
• W1971856495 cites W2047021275 @default.
• W1971856495 cites W2049477793 @default.
• W1971856495 cites W2054523068 @default.
• W1971856495 cites W2056550783 @default.
• W1971856495 cites W2056970184 @default.
• W1971856495 cites W2058660105 @default.
• W1971856495 cites W2060077561 @default.
• W1971856495 cites W2068964932 @default.
• W1971856495 cites W2070660603 @default.
• W1971856495 cites W2072137581 @default.
• W1971856495 cites W2073742373 @default.
• W1971856495 cites W2078037669 @default.
• W1971856495 cites W2078901357 @default.
• W1971856495 cites W2087188847 @default.
• W1971856495 cites W2088103235 @default.
• W1971856495 cites W2088168024 @default.
• W1971856495 cites W2088765380 @default.
• W1971856495 cites W2091027958 @default.
• W1971856495 cites W2093656025 @default.
• W1971856495 cites W2097950119 @default.
• W1971856495 cites W2101108802 @default.
• W1971856495 cites W2101626807 @default.
• W1971856495 cites W2111817213 @default.
• W1971856495 cites W2117029515 @default.
• W1971856495 cites W2136108338 @default.
• W1971856495 cites W2136983454 @default.
• W1971856495 cites W2145436604 @default.
• W1971856495 cites W2146394738 @default.
• W1971856495 cites W2150436777 @default.
• W1971856495 cites W2158732131 @default.
• W1971856495 cites W2160088845 @default.
• W1971856495 cites W2163421864 @default.
• W1971856495 cites W4232755968 @default.
• W1971856495 cites W4256681632 @default.
• W1971856495 cites W4293247451 @default.
• W1971856495 doi "https://doi.org/10.1016/j.brainresbull.2004.04.006" @default.
• W1971856495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15196660" @default.
• W1971856495 hasPublicationYear "2004" @default.
• W1971856495 type Work @default.
• W1971856495 sameAs 1971856495 @default.
• W1971856495 citedByCount "21" @default.
• W1971856495 countsByYear W19718564952014 @default.
• W1971856495 countsByYear W19718564952017 @default.
• W1971856495 countsByYear W19718564952020 @default.
• W1971856495 countsByYear W19718564952021 @default.
• W1971856495 countsByYear W19718564952022 @default.
• W1971856495 crossrefType "journal-article" @default.
• W1971856495 hasAuthorship W1971856495A5052999091 @default.
• W1971856495 hasAuthorship W1971856495A5079146016 @default.
• W1971856495 hasAuthorship W1971856495A5089423495 @default.
• W1971856495 hasConcept C11960822 @default.
• W1971856495 hasConcept C126322002 @default.
• W1971856495 hasConcept C134018914 @default.
• W1971856495 hasConcept C185592680 @default.
• W1971856495 hasConcept C195794163 @default.
• W1971856495 hasConcept C22885893 @default.
• W1971856495 hasConcept C24998067 @default.

• next