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- W1971862017 abstract "By utilizing I131-labeled lente insulin, data from the study presented here suggest that the rates of clearance of insulin which may be expected when insulin is injected in the thigh differ from those which may be expected when it is injected into the upper arm. Such variability was not observed in relation to the tissue of injection. Similar rates of clearance were found following injections in both subcutaneous and intramuscular tissues. The interest of precise diabetic control would appear to be best served by consistently injecting insulin into the same anatomic region (e.g., the thigh), but by varying the sites within the region. Utilization of intramuscular tissue sites for injection provides a reasonable alternative to subcutaneous injections and could have application in the treatment and prevention of lipodystrophic complications. By utilizing I131-labeled lente insulin, data from the study presented here suggest that the rates of clearance of insulin which may be expected when insulin is injected in the thigh differ from those which may be expected when it is injected into the upper arm. Such variability was not observed in relation to the tissue of injection. Similar rates of clearance were found following injections in both subcutaneous and intramuscular tissues. The interest of precise diabetic control would appear to be best served by consistently injecting insulin into the same anatomic region (e.g., the thigh), but by varying the sites within the region. Utilization of intramuscular tissue sites for injection provides a reasonable alternative to subcutaneous injections and could have application in the treatment and prevention of lipodystrophic complications." @default.
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- W1971862017 date "1964-04-01" @default.
- W1971862017 modified "2023-10-14" @default.
- W1971862017 title "The route of insulin administration in the management of diabetes mellitus" @default.
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- W1971862017 doi "https://doi.org/10.1016/s0022-3476(64)80345-0" @default.
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