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• W1971874657 abstract "Tetraspanin protein CD151 on tumor cells supports invasion and metastasis. In the present study, we show that host animal CD151 also plays a critical role. CD151-null mice showed markedly diminished experimental lung metastasis after injection of Lewis lung carcinoma or B16F10 melanoma cells. Diminished tumor cell residence in the lungs was evident 6-24 hours after injection. Consistent with an endothelial cell deficiency, isolated CD151-null mouse lung endothelial cells showed diminished support for B16F10 adhesion and transendothelial migration, diminished B16F10-induced permeability, and diminished B16F10 adhesion to extracellular matrix deposited by CD151-null mouse lung endothelial cells. However, CD151 deletion did not affect the size of metastatic foci or subcutaneous primary B16F10 tumors, tumor aggregation, tumor clearance from the blood, or tumor-induced immune cell activation and recruitment. Therefore, the effects of host CD151 on metastasis do not involve altered local tumor growth or immune surveillance. VEGF-induced endothelial cell signaling through Src and Akt was diminished in CD151-null endothelial cells. However, deficient signaling was not accompanied by reduced endothelial permeability either in vitro (monolayer permeability assay) or in vivo (VEGF-stimulated Miles assay). In summary, diminished metastasis in CD151-null host animals may be due to impaired tumor-endothelial interactions, with underlying defects in mouse lung endothelial cell extracellular matrix production." @default.
• W1971874657 created "2016-06-24" @default.
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• W1971874657 date "2011-07-14" @default.
• W1971874657 modified "2023-10-16" @default.
• W1971874657 title "Diminished metastasis in tetraspanin CD151–knockout mice" @default.
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• W1971874657 doi "https://doi.org/10.1182/blood-2010-08-302240" @default.
• W1971874657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3138696" @default.
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• W1971874657 hasPublicationYear "2011" @default.
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