FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971878477> ?p ?o ?g. }

• W1971878477 endingPage "464" @default.
• W1971878477 startingPage "458" @default.
• W1971878477 abstract "In recent years, the use of bone marrow mesenchymal stem cell (BMSC) implantation has provided an alternative treatment for osteoarthritis. The objective of this study is to determine whether or not an intra-articular injection of a single dose of autologous chondrogenic induced BMSC could retard the progressive destruction of cartilage in a surgically induced osteoarthritis in sheep. Sheep BMSCs were isolated and divided into two groups. One group was cultured in chondrogenic media containing (Ham's F12:DMEM, 1:1) FD+1% FBS+5 ng/ml TGFβ3+50 ng/ml IGF-1 (CM), and the other group was cultured in the basal media, FD+10% FBS (BM). The procedure for surgically induced osteoarthritis was performed on the donor sheep 6 weeks prior to intra-articular injection into the knee joint of a single dose of BMSC from either group, suspended in 5 ml FD at density of 2 million cells/ml. The control groups were injected with basal media, without cells. Six weeks after injection, gross evidence of retardation of cartilage destruction was seen in the osteoarthritic knee joints treated with CM as well as BM. No significant ICRS (International Cartilage Repair Society) scoring was detected between the two groups with cells. However macroscopically, meniscus repair was observed in the knee joint treated with CM. Severe osteoarthritis and meniscal injury was observed in the control group. Interestingly, histologically the CM group demonstrated good cartilage histoarchitecture, thickness and quality, comparable to normal knee joint cartilage. As a conclusion, intra-articular injection of a single dose of BMSC either chondrogenically induced or not, could retard the progression of osteoarthritis (OA) in a sheep model, but the induced cells indicated better results especially in meniscus regeneration." @default.
• W1971878477 created "2016-06-24" @default.
• W1971878477 creator A5021590533 @default.
• W1971878477 creator A5038419928 @default.
• W1971878477 creator A5050218087 @default.
• W1971878477 creator A5067019152 @default.
• W1971878477 creator A5090096276 @default.
• W1971878477 date "2012-06-01" @default.
• W1971878477 modified "2023-10-17" @default.
• W1971878477 title "The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model" @default.
• W1971878477 cites W1942341118 @default.
• W1971878477 cites W1966095355 @default.
• W1971878477 cites W1966481701 @default.
• W1971878477 cites W1968746947 @default.
• W1971878477 cites W1969252625 @default.
• W1971878477 cites W1970839075 @default.
• W1971878477 cites W1971118654 @default.
• W1971878477 cites W1977970932 @default.
• W1971878477 cites W1996298757 @default.
• W1971878477 cites W1999014699 @default.
• W1971878477 cites W2002559995 @default.
• W1971878477 cites W2005201973 @default.
• W1971878477 cites W2008871778 @default.
• W1971878477 cites W2010779043 @default.
• W1971878477 cites W2011693143 @default.
• W1971878477 cites W2016671974 @default.
• W1971878477 cites W2016936906 @default.
• W1971878477 cites W2021164682 @default.
• W1971878477 cites W2025951027 @default.
• W1971878477 cites W2031668243 @default.
• W1971878477 cites W2041368501 @default.
• W1971878477 cites W2045452294 @default.
• W1971878477 cites W2054541694 @default.
• W1971878477 cites W2055694376 @default.
• W1971878477 cites W2058568261 @default.
• W1971878477 cites W2070435400 @default.
• W1971878477 cites W2074563703 @default.
• W1971878477 cites W2079010145 @default.
• W1971878477 cites W2083860653 @default.
• W1971878477 cites W2089915717 @default.
• W1971878477 cites W2093227644 @default.
• W1971878477 cites W2102373021 @default.
• W1971878477 cites W2112473705 @default.
• W1971878477 cites W2116500923 @default.
• W1971878477 cites W2118788475 @default.
• W1971878477 cites W2125361012 @default.
• W1971878477 cites W2125483070 @default.
• W1971878477 cites W2133985629 @default.
• W1971878477 cites W2150673069 @default.
• W1971878477 cites W2159778679 @default.
• W1971878477 cites W2161197962 @default.
• W1971878477 cites W4211147424 @default.
• W1971878477 cites W4211248981 @default.
• W1971878477 doi "https://doi.org/10.1016/j.exger.2012.03.018" @default.
• W1971878477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22759409" @default.
• W1971878477 hasPublicationYear "2012" @default.
• W1971878477 type Work @default.
• W1971878477 sameAs 1971878477 @default.
• W1971878477 citedByCount "130" @default.
• W1971878477 countsByYear W19718784772013 @default.
• W1971878477 countsByYear W19718784772014 @default.
• W1971878477 countsByYear W19718784772015 @default.
• W1971878477 countsByYear W19718784772016 @default.
• W1971878477 countsByYear W19718784772017 @default.
• W1971878477 countsByYear W19718784772018 @default.
• W1971878477 countsByYear W19718784772019 @default.
• W1971878477 countsByYear W19718784772020 @default.
• W1971878477 countsByYear W19718784772021 @default.
• W1971878477 countsByYear W19718784772022 @default.
• W1971878477 countsByYear W19718784772023 @default.
• W1971878477 crossrefType "journal-article" @default.
• W1971878477 hasAuthorship W1971878477A5021590533 @default.
• W1971878477 hasAuthorship W1971878477A5038419928 @default.
• W1971878477 hasAuthorship W1971878477A5050218087 @default.
• W1971878477 hasAuthorship W1971878477A5067019152 @default.
• W1971878477 hasAuthorship W1971878477A5090096276 @default.
• W1971878477 hasBestOaLocation W19718784771 @default.
• W1971878477 hasConcept C105702510 @default.
• W1971878477 hasConcept C120665830 @default.
• W1971878477 hasConcept C121332964 @default.
• W1971878477 hasConcept C126322002 @default.
• W1971878477 hasConcept C141071460 @default.
• W1971878477 hasConcept C142724271 @default.
• W1971878477 hasConcept C189178095 @default.
• W1971878477 hasConcept C198826908 @default.
• W1971878477 hasConcept C204787440 @default.
• W1971878477 hasConcept C2776164576 @default.
• W1971878477 hasConcept C2778024521 @default.
• W1971878477 hasConcept C2779306644 @default.
• W1971878477 hasConcept C2780007613 @default.
• W1971878477 hasConcept C2780550940 @default.
• W1971878477 hasConcept C28328180 @default.
• W1971878477 hasConcept C2908736133 @default.
• W1971878477 hasConcept C3020332539 @default.
• W1971878477 hasConcept C35496256 @default.
• W1971878477 hasConcept C61511704 @default.
• W1971878477 hasConcept C71924100 @default.
• W1971878477 hasConcept C86803240 @default.

• next