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- W1971878510 abstract "Directed synthesis and pharmacological evaluation in a recently described class of α-phenoxyphenylacetic acid bearing angiotensin II (AII) receptor antagonists has afforded further potent AT 1 -selective AII antagonists. Substitution in the central aromatic ring significantly increases AT 2 receptor affinity such that the n -propyl derivative 7g displayed low nanomolar potency at both AT 1 and AT 2 receptor subtypes. SAR studies for a recently described class of α-phenoxyphenylacetic acid derived All antagonists affords highly potent AT 1 -selective antagonists. An n -propyl substituent in the central aromatic ring ( 7g ) affords low nanomolar potency at both AT 1 and AT 2 receptor subtypes." @default.
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- W1971878510 date "1995-06-01" @default.
- W1971878510 modified "2023-09-27" @default.
- W1971878510 title "α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II)" @default.
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- W1971878510 doi "https://doi.org/10.1016/0960-894x(95)00185-v" @default.
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