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- W1971886591 abstract "Abstract Incorporation of glycine-2-C 14 into Hb proto and bile bilirubin was studied at short intervals in 2 bile fistula dogs during successive periods of inhibited and then stimulated erythropoiesis (plethora and bleeding in 1 dog and undefined illness and bleeding in another), and in a third dog with bile renal fistula but without disturbed erythropoiesis. Results support the concept of a nonerythropoietic component as a partial source of early-labeled bilirubin. Thus, during the period of inhibited erythropoiesis relatively larger amounts of bilirubin-C 14 were excreted during the first 48 hours. The total amount of this labeling was appreciably greater than that expected from the relatively low labeling of total circulating hemoglobinproto during this period compared to the postbleeding period. The per cent incorporation of glycine-C 14 in total circulating Hb proto during the postbleeding and plethoric periods, respectively, were 5.8 and 0.48 (ratio of 12.1), while the corresponding values for the total 6 day bile bilirubin-C 14 were 0.22 and 0.04 (ratio of 5.5). In an otherwise normal bile fistula dog given ALA-C 14 , 20 per cent of the C 14 administered was recovered as bile bilirubin-C 14 during the following 6 days, with 94 per cent of this amount appearing during the first 2 days. Peak activity at 3–4 hours was 22 × 10 6 dpm/mg./mc. dose. Only 0.26 per cent of the dose was incorporated in circulating Hb proto in contrast to 3.0 per cent in the normal dog given glycine-C 14 . In a second dog studied for only 24 hours, 19.5 per cent of the administered dose of ALA-C 14 was excreted as bile bilirubin-C 14 ." @default.
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- W1971886591 date "1966-12-01" @default.
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- W1971886591 title "Early labeling of bilirubin from glycine and δ-aminolevulinic acid in bile fistula dogs, with special reference to stimulated versus suppressed erythropoiesis" @default.
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- W1971886591 doi "https://doi.org/10.1016/0026-0495(66)90103-x" @default.
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