FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971887012> ?p ?o ?g. }

• W1971887012 abstract "Fluoride mouthrinses have been used extensively as a caries-preventive intervention in school-based programmes and by individuals at home. This is an update of the Cochrane review of fluoride mouthrinses for preventing dental caries in children and adolescents that was first published in 2003.The primary objective is to determine the effectiveness and safety of fluoride mouthrinses in preventing dental caries in the child and adolescent population.The secondary objective is to examine whether the effect of fluoride rinses is influenced by:• initial level of caries severity;• background exposure to fluoride in water (or salt), toothpastes or reported fluoride sources other than the study option(s); or• fluoride concentration (ppm F) or frequency of use (times per year).We searched the following electronic databases: Cochrane Oral Health's Trials Register (whole database, to 22 April 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2016, Issue 3), MEDLINE Ovid (1946 to 22 April 2016), Embase Ovid (1980 to 22 April 2016), CINAHL EBSCO (the Cumulative Index to Nursing and Allied Health Literature, 1937 to 22 April 2016), LILACS BIREME (Latin American and Caribbean Health Science Information Database, 1982 to 22 April 2016), BBO BIREME (Bibliografia Brasileira de Odontologia; from 1986 to 22 April 2016), Proquest Dissertations and Theses (1861 to 22 April 2016) and Web of Science Conference Proceedings (1990 to 22 April 2016). We undertook a search for ongoing trials on the US National Institutes of Health Trials Register (http://clinicaltrials.gov) and the World Health Organization International Clinical Trials Registry Platform. We placed no restrictions on language or date of publication when searching electronic databases. We also searched reference lists of articles and contacted selected authors and manufacturers.Randomised or quasi-randomised controlled trials where blind outcome assessment was stated or indicated, comparing fluoride mouthrinse with placebo or no treatment in children up to 16 years of age. Study duration had to be at least one year. The main outcome was caries increment measured by the change in decayed, missing and filled tooth surfaces in permanent teeth (D(M)FS).At least two review authors independently performed study selection, data extraction and risk of bias assessment. We contacted study authors for additional information when required. The primary measure of effect was the prevented fraction (PF), that is, the difference in mean caries increments between treatment and control groups expressed as a percentage of the mean increment in the control group. We conducted random-effects meta-analyses where data could be pooled. We examined potential sources of heterogeneity in random-effects metaregression analyses. We collected adverse effects information from the included trials.In this review, we included 37 trials involving 15,813 children and adolescents. All trials tested supervised use of fluoride mouthrinse in schools, with two studies also including home use. Almost all children received a fluoride rinse formulated with sodium fluoride (NaF), mostly on either a daily or weekly/fortnightly basis and at two main strengths, 230 or 900 ppm F, respectively. Most studies (28) were at high risk of bias, and nine were at unclear risk of bias.From the 35 trials (15,305 participants) that contributed data on permanent tooth surface for meta-analysis, the D(M)FS pooled PF was 27% (95% confidence interval (CI), 23% to 30%; I(2) = 42%) (moderate quality evidence). We found no significant association between estimates of D(M)FS prevented fractions and baseline caries severity, background exposure to fluorides, rinsing frequency or fluoride concentration in metaregression analyses. A funnel plot of the 35 studies in the D(M)FS PF meta-analysis indicated no relationship between prevented fraction and study precision (no evidence of reporting bias). The pooled estimate of D(M)FT PF was 23% (95% CI, 18% to 29%; I² = 54%), from the 13 trials that contributed data for the permanent teeth meta-analysis (moderate quality evidence).We found limited information concerning possible adverse effects or acceptability of the treatment regimen in the included trials. Three trials incompletely reported data on tooth staining, and one trial incompletely reported information on mucosal irritation/allergic reaction. None of the trials reported on acute adverse symptoms during treatment.This review found that supervised regular use of fluoride mouthrinse by children and adolescents is associated with a large reduction in caries increment in permanent teeth. We are moderately certain of the size of the effect. Most of the evidence evaluated use of fluoride mouthrinse supervised in a school setting, but the findings may be applicable to children in other settings with supervised or unsupervised rinsing, although the size of the caries-preventive effect is less clear. Any future research on fluoride mouthrinses should focus on head-to-head comparisons between different fluoride rinse features or fluoride rinses against other preventive strategies, and should evaluate adverse effects and acceptability." @default.
• W1971887012 created "2016-06-24" @default.
• W1971887012 creator A5040576917 @default.
• W1971887012 creator A5045126942 @default.
• W1971887012 creator A5052811241 @default.
• W1971887012 creator A5077243752 @default.
• W1971887012 date "2016-07-29" @default.
• W1971887012 modified "2023-10-16" @default.
• W1971887012 title "Fluoride mouthrinses for preventing dental caries in children and adolescents" @default.
• W1971887012 cites W14105672 @default.
• W1971887012 cites W143170098 @default.
• W1971887012 cites W1508546387 @default.
• W1971887012 cites W1524298720 @default.
• W1971887012 cites W1555243689 @default.
• W1971887012 cites W1596484239 @default.
• W1971887012 cites W1691330820 @default.
• W1971887012 cites W1889568037 @default.
• W1971887012 cites W1901133259 @default.
• W1971887012 cites W1905939764 @default.
• W1971887012 cites W1965851586 @default.
• W1971887012 cites W1970071677 @default.
• W1971887012 cites W1971887012 @default.
• W1971887012 cites W1973430480 @default.
• W1971887012 cites W1973700396 @default.
• W1971887012 cites W1974065696 @default.
• W1971887012 cites W1975063565 @default.
• W1971887012 cites W1975847884 @default.
• W1971887012 cites W1976408268 @default.
• W1971887012 cites W1978654895 @default.
• W1971887012 cites W1981527038 @default.
• W1971887012 cites W1983046118 @default.
• W1971887012 cites W1986013377 @default.
• W1971887012 cites W1988937212 @default.
• W1971887012 cites W1989488835 @default.
• W1971887012 cites W1990870198 @default.
• W1971887012 cites W1995585047 @default.
• W1971887012 cites W1995640003 @default.
• W1971887012 cites W1996190021 @default.
• W1971887012 cites W1996285463 @default.
• W1971887012 cites W2000111956 @default.
• W1971887012 cites W2003352166 @default.
• W1971887012 cites W2003944865 @default.
• W1971887012 cites W2004563971 @default.
• W1971887012 cites W2006645914 @default.
• W1971887012 cites W2010701044 @default.
• W1971887012 cites W2011795179 @default.
• W1971887012 cites W2012520767 @default.
• W1971887012 cites W2014059128 @default.
• W1971887012 cites W2014460531 @default.
• W1971887012 cites W2017861463 @default.
• W1971887012 cites W2018628754 @default.
• W1971887012 cites W2020904343 @default.
• W1971887012 cites W2022460692 @default.
• W1971887012 cites W2026261179 @default.
• W1971887012 cites W2032762524 @default.
• W1971887012 cites W2034006983 @default.
• W1971887012 cites W2035038890 @default.
• W1971887012 cites W2045254920 @default.
• W1971887012 cites W2049272040 @default.
• W1971887012 cites W2054524965 @default.
• W1971887012 cites W2060712172 @default.
• W1971887012 cites W2062321355 @default.
• W1971887012 cites W2065905104 @default.
• W1971887012 cites W2067281664 @default.
• W1971887012 cites W2068650540 @default.
• W1971887012 cites W2068657383 @default.
• W1971887012 cites W2070800716 @default.
• W1971887012 cites W2071215595 @default.
• W1971887012 cites W2075608100 @default.
• W1971887012 cites W2077513915 @default.
• W1971887012 cites W2077556352 @default.
• W1971887012 cites W2077896370 @default.
• W1971887012 cites W2079081884 @default.
• W1971887012 cites W2080703901 @default.
• W1971887012 cites W2082770013 @default.
• W1971887012 cites W2087117600 @default.
• W1971887012 cites W2089688892 @default.
• W1971887012 cites W2089871984 @default.
• W1971887012 cites W2090893246 @default.
• W1971887012 cites W2091667030 @default.
• W1971887012 cites W2092045320 @default.
• W1971887012 cites W2093865902 @default.
• W1971887012 cites W2095565025 @default.
• W1971887012 cites W2096827149 @default.
• W1971887012 cites W2099704350 @default.
• W1971887012 cites W2105307776 @default.
• W1971887012 cites W2106595248 @default.
• W1971887012 cites W2107971163 @default.
• W1971887012 cites W2108969647 @default.
• W1971887012 cites W2113434897 @default.
• W1971887012 cites W2117257551 @default.
• W1971887012 cites W2117735592 @default.
• W1971887012 cites W2122421486 @default.
• W1971887012 cites W2124107041 @default.
• W1971887012 cites W2133820221 @default.
• W1971887012 cites W2135508699 @default.
• W1971887012 cites W2139605453 @default.
• W1971887012 cites W2141824074 @default.
• W1971887012 cites W2146460677 @default.
• W1971887012 cites W2149258554 @default.

• next