Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971891557> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W1971891557 endingPage "12" @default.
- W1971891557 startingPage "12" @default.
- W1971891557 abstract "The recent paper by Ishida et al.1 examines the role of leukocytes, specifically T lymphocytes, in vascular remodeling and vaso-obliteration in the rat eye. The authors conclude that T lymphocytes bind to the vasculature and model it by using Fas ligand (FasL) to prune the developing vessels. The authors also conclude from their examination of oxygen-induced vaso-obliteration that FasL on T lymphocytes induces apoptosis of hyperoxygenated endothelial cells. For these observations to have biological relevance, they should transcend species specificity. Because similar models of retinal angiogenesis exist in the mouse, one should be able to use the mouse to test predictions arising from these important observations. First, if Fas-FasL interactions are involved in retinal vessel development, Fas-deficient (lpr) and FasL-deficient (gld) mice should show vascular defects. Second, vessels in mice without these proteins should not undergo vaso-obliteration to the same degree as do wild-type animals. Third, rodents without T lymphocytes (Rag-/- or severe combined immunodeficient mice and T-cell-deficient rats) and/or cytotoxic lymphocytes (MHC class I− or CD8-deficient) should show aberrant retinal vessel development. Fourth, if the retinal vessels in these mice do not develop normally, this should severely impair normal development of the retina. Fifth, examination of these strains for vaso-obliteration should reveal that this process is severely impaired compared with wild-type animals." @default.
- W1971891557 created "2016-06-24" @default.
- W1971891557 creator A5030800645 @default.
- W1971891557 creator A5045207583 @default.
- W1971891557 date "2004-01-01" @default.
- W1971891557 modified "2023-09-26" @default.
- W1971891557 title "FasL, leukocytes and vascular modeling" @default.
- W1971891557 cites W1550758600 @default.
- W1971891557 cites W1978018492 @default.
- W1971891557 cites W1987941597 @default.
- W1971891557 cites W1989400519 @default.
- W1971891557 cites W2021409647 @default.
- W1971891557 cites W2055148837 @default.
- W1971891557 cites W2080333440 @default.
- W1971891557 cites W2089702990 @default.
- W1971891557 doi "https://doi.org/10.1038/nm0104-12" @default.
- W1971891557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14702618" @default.
- W1971891557 hasPublicationYear "2004" @default.
- W1971891557 type Work @default.
- W1971891557 sameAs 1971891557 @default.
- W1971891557 citedByCount "1" @default.
- W1971891557 crossrefType "journal-article" @default.
- W1971891557 hasAuthorship W1971891557A5030800645 @default.
- W1971891557 hasAuthorship W1971891557A5045207583 @default.
- W1971891557 hasBestOaLocation W19718915571 @default.
- W1971891557 hasConcept C190283241 @default.
- W1971891557 hasConcept C203014093 @default.
- W1971891557 hasConcept C31573885 @default.
- W1971891557 hasConcept C54355233 @default.
- W1971891557 hasConcept C66008609 @default.
- W1971891557 hasConcept C70721500 @default.
- W1971891557 hasConcept C71924100 @default.
- W1971891557 hasConcept C86803240 @default.
- W1971891557 hasConceptScore W1971891557C190283241 @default.
- W1971891557 hasConceptScore W1971891557C203014093 @default.
- W1971891557 hasConceptScore W1971891557C31573885 @default.
- W1971891557 hasConceptScore W1971891557C54355233 @default.
- W1971891557 hasConceptScore W1971891557C66008609 @default.
- W1971891557 hasConceptScore W1971891557C70721500 @default.
- W1971891557 hasConceptScore W1971891557C71924100 @default.
- W1971891557 hasConceptScore W1971891557C86803240 @default.
- W1971891557 hasIssue "1" @default.
- W1971891557 hasLocation W19718915571 @default.
- W1971891557 hasLocation W19718915572 @default.
- W1971891557 hasOpenAccess W1971891557 @default.
- W1971891557 hasPrimaryLocation W19718915571 @default.
- W1971891557 hasRelatedWork W1985715529 @default.
- W1971891557 hasRelatedWork W1997785635 @default.
- W1971891557 hasRelatedWork W2000981171 @default.
- W1971891557 hasRelatedWork W2049423875 @default.
- W1971891557 hasRelatedWork W2088311361 @default.
- W1971891557 hasRelatedWork W2110252365 @default.
- W1971891557 hasRelatedWork W2185164724 @default.
- W1971891557 hasRelatedWork W2367946196 @default.
- W1971891557 hasRelatedWork W2464691289 @default.
- W1971891557 hasRelatedWork W3015843261 @default.
- W1971891557 hasVolume "10" @default.
- W1971891557 isParatext "false" @default.
- W1971891557 isRetracted "false" @default.
- W1971891557 magId "1971891557" @default.
- W1971891557 workType "article" @default.