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- W1971905646 abstract "Venous thrombosis is a risk factor for oral estrogen treatment in men and women. Platelet responses mediated through estrogen receptors may be involved in these processes. However, expression of estrogen receptors and estrogen receptor-associated protein have not been defined clearly in human platelets. Therefore, the present study was designed to characterize estrogen receptors and estrogen receptor-associated proteins in human platelets. Platelets were obtained from normal female and male blood donors between the ages of 25 and 65 years. Estrogen receptors (ER f and ER g ), heat shock proteins (hsp70 and hsp90), endothelial nitric oxide synthases (eNOS), caveolin-1, -2 and -3 and calmodulin were analyzed in total platelet lysate by immunoblotting. Expression of ER f and ER g , hsp70, hsp90, eNOS, calmodulin, and caveolin-1 were observed in both sexes. Expression of all proteins was similar in platelets from males and females. Results of the present study suggest for the first time that both estrogen receptors f and g , caveolin-1 and other proteins associated with estrogen receptors and production of nitric oxide are present in platelets of both males and females." @default.
- W1971905646 created "2016-06-24" @default.
- W1971905646 creator A5040832215 @default.
- W1971905646 creator A5068205593 @default.
- W1971905646 date "2003-01-01" @default.
- W1971905646 modified "2023-10-08" @default.
- W1971905646 title "Human platelets contain estrogen receptor α, caveolin-1 and estrogen receptor associated proteins" @default.
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- W1971905646 doi "https://doi.org/10.1080/0953710031000080562" @default.
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