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- W1971909601 abstract "Evidence is presented for the existence within the hypothalamus of the Japanese quail (Coturnix coturnix japonica) of an activity which stimulates the release in vitro of avian pituitary gonadotropins. In 18 experiments involving 43 incubations with acidic hypothalamic extracts the rate of gonadotropin release from chicken pituitaries was significantly greater than with cortical extracts on 37 occasions. Taken overall the mean increase in rate was highly significantly different. Cortical extracts were no more effective than saline in evoking hormone release. The rate of secretion of gonadotropins was proportional to the quantity of hypothalamic extract.The activity is not due to hypothalamic gonadotropins since the extracts were ineffective if given to the assay chicks while boiling did not affect their releasing potency. Quail pituitary gonadotropins are destroyed by such a procedure. The activity does not result from synergism between hypothalamic extracts and the gonadotropins secreted into the medium. Releasing activity is not present in other areas of the quail brain or in the liver.Changes in the hypothalamic content of releasing activity are related to the reproductive state of the bird. It is not present in birds reared under short daily photoperiods. The chemical nature of the factors or factors is unknown although the following were ineffective: vasotocin, oxytocin, vasopressin, noradrenalin, dopamine, putrescine, histamine, and spermidine.The results are discussed in relation to recent studies on neuroendocrine control of gonadotropin secretion in birds." @default.
- W1971909601 created "2016-06-24" @default.
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- W1971909601 date "1970-08-01" @default.
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- W1971909601 title "Gonadotropin-releasing activity in the quail hypothalamus" @default.
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- W1971909601 doi "https://doi.org/10.1016/0016-6480(70)90107-3" @default.
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