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• W1971911119 abstract "Annals of the New York Academy of SciencesVolume 681, Issue 1 p. 529-538 Seronegative Myasthenia Gravis: Evidence for Plasma Factor(s) Interfering with Acetylcholine Receptor Functiona A. VINCENT, Corresponding Author A. VINCENTAddress for correspondence: Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.Search for more papers by this authorZ. LI, Z. LI Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorA. HART, A. HART Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorR. BARRETT-JOLLEY, R. BARRETT-JOLLEY Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorT. YAMAMOTO, T. YAMAMOTO Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorJ. BURGES, J. BURGES Department of Pharmacology Royal Free Hospital School of Medicine London, United KingdomSearch for more papers by this authorD. WRAY, D. WRAY Department of Pharmacology Royal Free Hospital School of Medicine London, United Kingdom Department of Pharmacology University of Leeds Leeds, United KingdomSearch for more papers by this authorN. BYRNE, N. BYRNE Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorP. MOLENAAR, P. MOLENAAR Department of Pharmacology University of Leiden Leiden, the NetherlandsSearch for more papers by this authorJ. NEWSOM-DAVIS, J. NEWSOM-DAVIS Department of Pharmacology Royal Free Hospital School of Medicine London, United KingdomSearch for more papers by this author A. VINCENT, Corresponding Author A. VINCENTAddress for correspondence: Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.Search for more papers by this authorZ. LI, Z. LI Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorA. HART, A. HART Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorR. BARRETT-JOLLEY, R. BARRETT-JOLLEY Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorT. YAMAMOTO, T. YAMAMOTO Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorJ. BURGES, J. BURGES Department of Pharmacology Royal Free Hospital School of Medicine London, United KingdomSearch for more papers by this authorD. WRAY, D. WRAY Department of Pharmacology Royal Free Hospital School of Medicine London, United Kingdom Department of Pharmacology University of Leeds Leeds, United KingdomSearch for more papers by this authorN. BYRNE, N. BYRNE Department of Clinical Neurology University of Oxford Oxford, United KingdomSearch for more papers by this authorP. MOLENAAR, P. MOLENAAR Department of Pharmacology University of Leiden Leiden, the NetherlandsSearch for more papers by this authorJ. NEWSOM-DAVIS, J. NEWSOM-DAVIS Department of Pharmacology Royal Free Hospital School of Medicine London, United KingdomSearch for more papers by this author First published: June 1993 https://doi.org/10.1111/j.1749-6632.1993.tb22936.xCitations: 51 a J. Burges and R. Barrett-Jolley were supported by Action Research for the Crippled Child. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Vincent, A. & J. Newsom-davis. 1985. Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J. Neurol. Neurosurg. Psychiatry 48: 1246–1252. 2 Soliven, B. C., D. J. Lange, A. S. Penn et al. 1988. Seronegative myasthenia gravis. Neurology 38: 514–517. 3 Mossman, S., A. Vincent & J. Newsom-davis. 1986. Myasthenia gravis without acetylcholine receptor antibody: a distinct disease entity. Lancet i: 116–119. 4 Toyka, K. V., D. B. Drachman, D. E. Griffin, A. Pestronk, J. A. Winkelstein, K. H. Fischbeck & I. Kao. 1977. Myasthenia gravis: study of humoral immune mechanisms by passive transfer to mice. N. Engl. J. Med. 296: 125–131. 5 Wilson, S., A. Vincent & J. Newsom-davis. 1983. Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. I. Receptor degradation. J. Neurol. Neurosurg. Psychiatry 46: 377–382. 6 Mossman, S., A. Vincent, & J. Newsom-davis. 1988. Passive transfer of myasthenia gravis by immunoglobulins: lack of correlation between AChR with antibody bound, acetylcholine receptor loss and transmission defect. J. Neurol. Sci. 84: 15–28. 7 Molenaar, P. C. 1990. In Neuromuscular transmission: basic and applied aspects. A. Vincent and D. Wray & Eds. Manchester University Press. Manchester , UK . 8 Luther, M. A., R. Schoepfer, P. Whiting et al. 1989. A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671. J. Neurosci 9: 1082–1096. 9 Walker, R., A. Vincent & J. Newsom-davis. 1988. Immunological and pharmacological heterogeneity of alpha-bungarotoxin binding sites extracted from TE671 cells. J. Neuroimmunol. 19: 149–157. 10 Lang, B., G. Richardson, J. Rees, A. Vincent & J. Newsom-davis. 1988. Plasma from myasthenia gravis patients reduces acetylcholine receptor agonist-induced Na+ flux into TE671 cell line. J. Neuroimmunol. 19: 141–148. 11 Yamamoto, T., A. Vincent, T. A. Ciulla, B. Lang, I. Johnston & J. Newsom-davis. 1991. Seronegative myasthenia gravis: A plasma factor inhibiting agonist-induced acetylcholine receptor function copurifies with IgM. Ann. Neurol. 30: 550–557. 12 Barrett-jolley, R., N. G. Byrne, J. Newsom-davis & A. Vincent. 1992. Inhibition of ACh-currents by human plasma in a whole-cell voltage-clamped human muscle cell line. J. Physiol. Lond. 446: 267P. 13 Willcox, N., M. Schluep, M. A. Ritter & J. Newsom-davis. 1991. The thymus in seronegative myasthenia gravis patients. J. Neurol. 238: 256–261. 14 Pestronk, A., D. B. Drachman & S. B. Self. 1985. Measurement of junctional acetylcholine receptors in myasthenia gravis: clinical correlates. Muscle & Nerve 8: 245–251. 15 Ito, Y., R. Miledi, A. Vincent & J. Newsom-davis. 1978. Acetylcholine receptors and end-plate electrophysiology in myasthenia gravis. Brain 101: 345–368. 16 Brooks, E. B., A. R. Pachner, D. B. Drachman & F. S. Kantor. 1990. A sensitive resetting assay for detection of acetylcholine receptor antibodies using BC3H-1 cells: Positive results in “antibody-negative” myasthenia gravis. J. Neuroimmunol. 28: 83–93. Citing Literature Volume681, Issue1Myasthenia Gravis and Related Disorders: Experimental and Clinical AspectsJune 1993Pages 529-538 ReferencesRelatedInformation" @default.
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