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• W1971926198 abstract "Obstructive sleep apnea (OSA) has been associated with increased systemic inflammatory responses that may contribute to an increased risk for end-organ morbidity. The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients. Consecutive non-obese children (aged 4–9 years) who were polysomnographically diagnosed with OSA, and age-, gender-, ethnicity-, and BMI-matched control children underwent a blood draw the next morning after a sleep study and plasma samples were assayed for interleukins 6 (IL-6) and 10 (IL-10). These tests were repeated 4–6 months after tonsillectomy and adenoidectomy (T&A) in children with OSA. IL-6 levels were higher and IL-10 plasma levels were lower in children with OSA and returned to control levels after T&A. Systemic inflammation is a constitutive component and consequence of OSA in many children, even in the absence of obesity, and is reversible upon treatment in most patients." @default.
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• W1971926198 date "2008-03-01" @default.
• W1971926198 modified "2023-10-17" @default.
• W1971926198 title "Systemic inflammation in non-obese children with obstructive sleep apnea" @default.
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• W1971926198 doi "https://doi.org/10.1016/j.sleep.2007.04.013" @default.
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