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• W1971928146 startingPage "137" @default.
• W1971928146 abstract "The antinociceptive action of four Ca2+ channel blockers, nifedipine, nimodipine, verapamil and diltiazem, was evaluated and compared to that of morphine using three algesiometric tests in mice and rats, namely, formalin, writhing and modified hot-plate test. Dose-response curves for all the drugs tested were similar and a significant dose-dependent antinociceptive action was evident in the formalin and writhing tests. However, in the hot-plate test, only nimodipine exhibited a significant analgesic effect, confirming the misleading results previously reported for this test. The findings suggest a pharmacological role of Ca2+ channel blockers in the modulation of antinociception under acute conditions. The analgesic action of Ca2+ channel blockers could be mediated by an increase in the nociceptive threshold resulting from interference with Ca2+ influx at opioid receptors, because Ca2+ influx is critical for the release of neurotransmitters and other substances implicated in nociception and inflammation. It is suggested that if a substance has a Ca2+ channel blocking effect, it should probably have some antinociceptive properties." @default.
• W1971928146 created "2016-06-24" @default.
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• W1971928146 date "1992-07-01" @default.
• W1971928146 modified "2023-10-18" @default.
• W1971928146 title "Antinociceptive effects of Ca2+ channel blockers" @default.
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• W1971928146 doi "https://doi.org/10.1016/0014-2999(92)90833-p" @default.
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