Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971930783> ?p ?o ?g. }
- W1971930783 endingPage "372" @default.
- W1971930783 startingPage "367" @default.
- W1971930783 abstract "We have previously shown that a high cholesterol (HC) diet results in increases in microglia load and levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in the brains of wild type (WT) and apolipoprotein E knockout (ApoE-/-) mice. In the present investigation, we analyzed whether treatment with rosuvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, would prevent the increases in inflammatory microglia and IL-6 levels in the brain and plasma of WT and ApoE-/- mice. We report that a HC diet resulted in an increased microglia load in the brains of WT and ApoE-/- mice, in support of our previous study. Treatment with rosuvastatin significantly decreased the microglia load in the brains of WT and ApoE-/- mice on a HC diet. Rosuvastatin treatment resulted in lowered plasma IL-6 levels in WT mice on a HC diet. However, in the present study the number of IL-6 positive cells in the brain was not significantly affected by a HC diet. A recent clinical study has shown that rosuvastatin reduces risk of ischemic stroke in patients with high plasma levels of the inflammatory marker C-reactive protein by 50%. The results from our study show that rosuvastatin reduces inflammatory cells in the brain. This finding is essential for furthering the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and stroke." @default.
- W1971930783 created "2016-06-24" @default.
- W1971930783 creator A5003298952 @default.
- W1971930783 creator A5049928775 @default.
- W1971930783 creator A5083928049 @default.
- W1971930783 date "2010-11-01" @default.
- W1971930783 modified "2023-09-27" @default.
- W1971930783 title "Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; Implications for prevention of stroke and AD" @default.
- W1971930783 cites W1500145074 @default.
- W1971930783 cites W1967695807 @default.
- W1971930783 cites W1970106273 @default.
- W1971930783 cites W1973216353 @default.
- W1971930783 cites W1988254695 @default.
- W1971930783 cites W1991050870 @default.
- W1971930783 cites W1998664054 @default.
- W1971930783 cites W1999631936 @default.
- W1971930783 cites W2001361004 @default.
- W1971930783 cites W2003188394 @default.
- W1971930783 cites W2004349651 @default.
- W1971930783 cites W2007229760 @default.
- W1971930783 cites W2015034968 @default.
- W1971930783 cites W2019070297 @default.
- W1971930783 cites W2021652661 @default.
- W1971930783 cites W2030782357 @default.
- W1971930783 cites W2032159032 @default.
- W1971930783 cites W2034337512 @default.
- W1971930783 cites W2035252462 @default.
- W1971930783 cites W2035713503 @default.
- W1971930783 cites W2037099926 @default.
- W1971930783 cites W2039814869 @default.
- W1971930783 cites W2040815013 @default.
- W1971930783 cites W2055680859 @default.
- W1971930783 cites W2061883196 @default.
- W1971930783 cites W2071695496 @default.
- W1971930783 cites W2073481032 @default.
- W1971930783 cites W2080676389 @default.
- W1971930783 cites W2080742766 @default.
- W1971930783 cites W2084226102 @default.
- W1971930783 cites W2090816846 @default.
- W1971930783 cites W2094353481 @default.
- W1971930783 cites W2097021098 @default.
- W1971930783 cites W2099556509 @default.
- W1971930783 cites W2119120508 @default.
- W1971930783 cites W2133982451 @default.
- W1971930783 cites W2138769898 @default.
- W1971930783 cites W2142746589 @default.
- W1971930783 cites W2145123193 @default.
- W1971930783 cites W2150191386 @default.
- W1971930783 cites W2163481458 @default.
- W1971930783 cites W37616696 @default.
- W1971930783 cites W4376633725 @default.
- W1971930783 cites W1669330753 @default.
- W1971930783 doi "https://doi.org/10.1016/j.bbrc.2010.10.035" @default.
- W1971930783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20946880" @default.
- W1971930783 hasPublicationYear "2010" @default.
- W1971930783 type Work @default.
- W1971930783 sameAs 1971930783 @default.
- W1971930783 citedByCount "14" @default.
- W1971930783 countsByYear W19719307832012 @default.
- W1971930783 countsByYear W19719307832014 @default.
- W1971930783 countsByYear W19719307832016 @default.
- W1971930783 countsByYear W19719307832017 @default.
- W1971930783 countsByYear W19719307832019 @default.
- W1971930783 countsByYear W19719307832021 @default.
- W1971930783 countsByYear W19719307832022 @default.
- W1971930783 crossrefType "journal-article" @default.
- W1971930783 hasAuthorship W1971930783A5003298952 @default.
- W1971930783 hasAuthorship W1971930783A5049928775 @default.
- W1971930783 hasAuthorship W1971930783A5083928049 @default.
- W1971930783 hasConcept C11988809 @default.
- W1971930783 hasConcept C126322002 @default.
- W1971930783 hasConcept C134018914 @default.
- W1971930783 hasConcept C170493617 @default.
- W1971930783 hasConcept C182704531 @default.
- W1971930783 hasConcept C2776914184 @default.
- W1971930783 hasConcept C2778163477 @default.
- W1971930783 hasConcept C2779134260 @default.
- W1971930783 hasConcept C2779830541 @default.
- W1971930783 hasConcept C2780499067 @default.
- W1971930783 hasConcept C57089818 @default.
- W1971930783 hasConcept C71924100 @default.
- W1971930783 hasConceptScore W1971930783C11988809 @default.
- W1971930783 hasConceptScore W1971930783C126322002 @default.
- W1971930783 hasConceptScore W1971930783C134018914 @default.
- W1971930783 hasConceptScore W1971930783C170493617 @default.
- W1971930783 hasConceptScore W1971930783C182704531 @default.
- W1971930783 hasConceptScore W1971930783C2776914184 @default.
- W1971930783 hasConceptScore W1971930783C2778163477 @default.
- W1971930783 hasConceptScore W1971930783C2779134260 @default.
- W1971930783 hasConceptScore W1971930783C2779830541 @default.
- W1971930783 hasConceptScore W1971930783C2780499067 @default.
- W1971930783 hasConceptScore W1971930783C57089818 @default.
- W1971930783 hasConceptScore W1971930783C71924100 @default.
- W1971930783 hasIssue "2" @default.
- W1971930783 hasLocation W19719307831 @default.
- W1971930783 hasLocation W19719307832 @default.
- W1971930783 hasOpenAccess W1971930783 @default.
- W1971930783 hasPrimaryLocation W19719307831 @default.