FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971931966> ?p ?o ?g. }

• W1971931966 endingPage "e53150" @default.
• W1971931966 startingPage "e53150" @default.
• W1971931966 abstract "The forkhead transcription factor FOXP3 is necessary for induction of regulatory T lymphocytes (Tregs) and their immunosuppressive function. We have previously demonstrated that targeting Tregs by vaccination of mice with murine FOXP3 mRNA-transfected dendritic cells (DCs) elicits FOXP3-specific T cell responses and enhances tumor immunity. It is clear that FOXP3 expression is not restricted to T-cell lineage and herein, using RT-PCR, flow cytometry, and western immunoblot we demonstrate for the first time that FOXP3 is expressed in inflammatory breast cancer (IBC) cells, SUM149 (triple negative, ErbB1-activated) and SUM190 (ErbB2-overexpressing). Importantly, FOXP3-specific T cells generated in vitro using human FOXP3 RNA-transfected DCs as stimulators efficiently lyse SUM149 cells. Interestingly, an isogenic model (rSUM149) derived from SUM149 with an enhanced anti-apoptotic phenotype was resistant to FOXP3-specific T cell mediated lysis. The MHC class I cellular processing mechanism was intact in both cell lines at the protein and transcription levels suggesting that the resistance to cytolysis by rSUM149 cells was not related to MHC class I expression or to the MHC class I antigen processing machinery in these cells. Our data suggest that FOXP3 may be an effective tumor target in IBC cells however increased anti-apoptotic signaling can lead to immune evasion." @default.
• W1971931966 created "2016-06-24" @default.
• W1971931966 creator A5012031316 @default.
• W1971931966 creator A5012804507 @default.
• W1971931966 creator A5013753246 @default.
• W1971931966 creator A5050552623 @default.
• W1971931966 creator A5051436334 @default.
• W1971931966 creator A5073754557 @default.
• W1971931966 creator A5074731037 @default.
• W1971931966 creator A5077103987 @default.
• W1971931966 creator A5081680623 @default.
• W1971931966 creator A5089632095 @default.
• W1971931966 creator A5090164724 @default.
• W1971931966 date "2013-01-14" @default.
• W1971931966 modified "2023-10-13" @default.
• W1971931966 title "Immunologic Targeting of FOXP3 in Inflammatory Breast Cancer Cells" @default.
• W1971931966 cites W1489870404 @default.
• W1971931966 cites W1514059715 @default.
• W1971931966 cites W1539934168 @default.
• W1971931966 cites W1603680605 @default.
• W1971931966 cites W1933205452 @default.
• W1971931966 cites W1963858122 @default.
• W1971931966 cites W1969037652 @default.
• W1971931966 cites W1970324691 @default.
• W1971931966 cites W1973249762 @default.
• W1971931966 cites W1997751635 @default.
• W1971931966 cites W2003128034 @default.
• W1971931966 cites W2014029787 @default.
• W1971931966 cites W2016316937 @default.
• W1971931966 cites W2016910978 @default.
• W1971931966 cites W2017678652 @default.
• W1971931966 cites W2018365200 @default.
• W1971931966 cites W2019104791 @default.
• W1971931966 cites W2032561335 @default.
• W1971931966 cites W2034625094 @default.
• W1971931966 cites W2041629170 @default.
• W1971931966 cites W2044764392 @default.
• W1971931966 cites W2050938549 @default.
• W1971931966 cites W2052329251 @default.
• W1971931966 cites W2055503775 @default.
• W1971931966 cites W2081904025 @default.
• W1971931966 cites W2085018432 @default.
• W1971931966 cites W2092590786 @default.
• W1971931966 cites W2097811455 @default.
• W1971931966 cites W2101962857 @default.
• W1971931966 cites W2102660250 @default.
• W1971931966 cites W2106728539 @default.
• W1971931966 cites W2107123646 @default.
• W1971931966 cites W2109351460 @default.
• W1971931966 cites W2114185671 @default.
• W1971931966 cites W2114701172 @default.
• W1971931966 cites W2116576993 @default.
• W1971931966 cites W2121383044 @default.
• W1971931966 cites W2122722718 @default.
• W1971931966 cites W2125202200 @default.
• W1971931966 cites W2125988618 @default.
• W1971931966 cites W2128058116 @default.
• W1971931966 cites W2131774025 @default.
• W1971931966 cites W2139059024 @default.
• W1971931966 cites W2140111836 @default.
• W1971931966 cites W2140633375 @default.
• W1971931966 cites W2141785549 @default.
• W1971931966 cites W2142057493 @default.
• W1971931966 cites W2150678612 @default.
• W1971931966 cites W2153282879 @default.
• W1971931966 cites W2160117150 @default.
• W1971931966 cites W2161393161 @default.
• W1971931966 cites W2162929947 @default.
• W1971931966 cites W2164540420 @default.
• W1971931966 cites W2165328065 @default.
• W1971931966 cites W2167523219 @default.
• W1971931966 doi "https://doi.org/10.1371/journal.pone.0053150" @default.
• W1971931966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3544902" @default.
• W1971931966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23341929" @default.
• W1971931966 hasPublicationYear "2013" @default.
• W1971931966 type Work @default.
• W1971931966 sameAs 1971931966 @default.
• W1971931966 citedByCount "16" @default.
• W1971931966 countsByYear W19719319662013 @default.
• W1971931966 countsByYear W19719319662014 @default.
• W1971931966 countsByYear W19719319662015 @default.
• W1971931966 countsByYear W19719319662016 @default.
• W1971931966 countsByYear W19719319662017 @default.
• W1971931966 countsByYear W19719319662022 @default.
• W1971931966 countsByYear W19719319662023 @default.
• W1971931966 crossrefType "journal-article" @default.
• W1971931966 hasAuthorship W1971931966A5012031316 @default.
• W1971931966 hasAuthorship W1971931966A5012804507 @default.
• W1971931966 hasAuthorship W1971931966A5013753246 @default.
• W1971931966 hasAuthorship W1971931966A5050552623 @default.
• W1971931966 hasAuthorship W1971931966A5051436334 @default.
• W1971931966 hasAuthorship W1971931966A5073754557 @default.
• W1971931966 hasAuthorship W1971931966A5074731037 @default.
• W1971931966 hasAuthorship W1971931966A5077103987 @default.
• W1971931966 hasAuthorship W1971931966A5081680623 @default.
• W1971931966 hasAuthorship W1971931966A5089632095 @default.
• W1971931966 hasAuthorship W1971931966A5090164724 @default.
• W1971931966 hasBestOaLocation W19719319661 @default.

• next