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- W1971942212 abstract "It is well known that the efficacy of an anti-cancer drug is closely related to the drug concentration at the cancer site. Therefore, intra-arterial chemotherapy is a highly attractive method because of its ability to achieve a high drug concentration in the tumor. The purpose of this paper is to address the feasibility, toxicity, and clinicopathological response of preoperative super-selective intra-arterial nedaplatin (CDGP) infusion and radiation therapy in patients with oral squamous cell carcinoma (OSCC). Seven patients with OSCC were treated with super-selective intra-arterial infusion of CDGP (60-86mg/m2) with concurrent radiation therapy (30Gy). All cases were men and the age ranged from 58-85. The primary sites of the tumor were tongue in 2 cases, oral floor in 2 cases, buccal mucosa, lower and upper gingiva in one case respectively. After clinical evaluation of the treatment, all patients underwent surgery as a therapeutic procedure. The treatment effects were assessed based on CT, MRI, visual examination and palpation conducted within 4 weeks after the preoperative treatment. Tumor response was classified as complete response (CR), partial response (PR) and no change (NC) according to the WHO response criteria. Histological effects were judged as grade I to IV according to Oboshi-Shimosato’s classification. Adverse toxic reactions were graded by the WHO scale. Clinically, a complete response was achieved in 5 patients (71%) and 2 patients exhibited a partial response (29%). Histological effects were Grade IV in 2 patients (29%), Grade III in 2 patients (29%) and Grade IIb in 3 patients (42%), respectively. The most common side-effect was mild or moderate local mucositis in the irradiated and infused area. Systemic toxicity was uncommon. Catheter-related complications did not occur in any of the cases. These results demonstrate that this preoperative combination therapy is safe, effective and confers reliable preoperative treatment, especially for elderly and medically-compromised patients with OSCC." @default.
- W1971942212 created "2016-06-24" @default.
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- W1971942212 date "2007-09-01" @default.
- W1971942212 modified "2023-09-23" @default.
- W1971942212 title "Poster 099: Clinicopathological Evaluation of Preoperative Intra-Arterial Nedaplatin Infusion and Concrrent Radiation Therapy for Oral Cancer" @default.
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- W1971942212 doi "https://doi.org/10.1016/j.joms.2007.06.368" @default.
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