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- W1971946675 abstract "In the past two decades, clinicians have become more aware of the profound effect of cognitive impairment in multiple sclerosis (MS). 40–65% of patients with MS have cognitive impairment, with involvement of memory, sustained attention, and information processing speed. 1 Bobholz JA Rao SM Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol. 2003; 16: 283-288 Crossref PubMed Scopus (342) Google Scholar Cognitive impairment can be detected in the early stages of MS, occurs in all disease subtypes, and typically progresses over time. 2 Amato MP Ponziani G Siracusa G Sorbi S Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol. 2001; 58: 1602-1606 Crossref PubMed Scopus (506) Google Scholar In MRI studies, deficits relate to brain-lesion burden and atrophy. 1 Bobholz JA Rao SM Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol. 2003; 16: 283-288 Crossref PubMed Scopus (342) Google Scholar Cognitive dysfunction can have a large effect on a patient's quality of life and can influence role fulfilment in work and social life independently of physical disability. 2 Amato MP Ponziani G Siracusa G Sorbi S Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol. 2001; 58: 1602-1606 Crossref PubMed Scopus (506) Google Scholar" @default.
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- W1971946675 date "2005-02-01" @default.
- W1971946675 modified "2023-09-27" @default.
- W1971946675 title "Donepezil for memory impairment in multiple sclerosis" @default.
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- W1971946675 doi "https://doi.org/10.1016/s1474-4422(05)00972-5" @default.
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