FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971953383> ?p ?o ?g. }

• W1971953383 endingPage "1130" @default.
• W1971953383 startingPage "1124" @default.
• W1971953383 abstract "The common acute lymphoblastic leukemia antigen (CALLA) is identical to human endopeptidase 24.11 (E-24.11) and is expressed on certain human melanoma lines. This work was conducted in order to investigate whether alphamelanocyte-stimulating hormone (alpha-MSH) could be a substrate for E-24.11, its degradation leading to the negative alpha-MSH radiobinding assay results observed with some CALLA-positive cell lines. We used 3 human melanoma cell lines (GLL-19, Mel Juso and G361) which lack receptors to alpha-MSH and express CALLA, and, as a control, one CALLA-negative melanoma cell line (HBL) with specific receptors for alpha-MSH. Radioimmunoassays give evidence that alpha-MSH was degraded in the presence of the 4 melanoma cell lines and that disappearance of the peptide was significantly reduced by phosphoramldon in 2 lines (GLL-19 and G361). Upon incubation of alpha-MSH with GLL-19 and G361 cell membranes, 3 degradation products were completely abolished in the presence of phosphoramidon. Amino acid content analysis of alpha-MSH fragments produced by purified E-24.11 permitted identification of 6 peptide bonds in the sequence of alpha-MSH susceptible to cleavage by the enzyme. It is concluded that alpha-MSH is a substrate in vitro for purified E-24.11 and for the enzyme present on the human melanoma cell lines GLL-19 and G361, expressing a high level of endopeptidase activity. However, hydrolysis of alpha-MSH by this enzyme does not seem to represent the main factor responsible for the apparent absence of receptors for the hormone on some cell lines." @default.
• W1971953383 created "2016-06-24" @default.
• W1971953383 creator A5003228111 @default.
• W1971953383 creator A5016601391 @default.
• W1971953383 creator A5028282419 @default.
• W1971953383 creator A5051298410 @default.
• W1971953383 creator A5051614904 @default.
• W1971953383 creator A5070383859 @default.
• W1971953383 creator A5080256420 @default.
• W1971953383 date "1990-12-15" @default.
• W1971953383 modified "2023-10-12" @default.
• W1971953383 title "Degradation of alpha-melanocyte stimulating hormone (alpha-MSH) by CALLA/endopeptidase 24. 11 expressed by human melanoma cells in culture" @default.
• W1971953383 cites W1543111690 @default.
• W1971953383 cites W1912014122 @default.
• W1971953383 cites W1970674978 @default.
• W1971953383 cites W1970716955 @default.
• W1971953383 cites W1977940155 @default.
• W1971953383 cites W1982782378 @default.
• W1971953383 cites W1987341100 @default.
• W1971953383 cites W1996129944 @default.
• W1971953383 cites W1998552617 @default.
• W1971953383 cites W2001681614 @default.
• W1971953383 cites W2017470279 @default.
• W1971953383 cites W2021212968 @default.
• W1971953383 cites W2024667090 @default.
• W1971953383 cites W2034351494 @default.
• W1971953383 cites W2036003081 @default.
• W1971953383 cites W2092895797 @default.
• W1971953383 cites W2093847450 @default.
• W1971953383 cites W2109980291 @default.
• W1971953383 cites W2122845914 @default.
• W1971953383 cites W2131904026 @default.
• W1971953383 cites W2150620539 @default.
• W1971953383 cites W2215820727 @default.
• W1971953383 cites W2416928114 @default.
• W1971953383 cites W2493568150 @default.
• W1971953383 cites W4293247451 @default.
• W1971953383 cites W89319841 @default.
• W1971953383 doi "https://doi.org/10.1002/ijc.2910460629" @default.
• W1971953383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2174414" @default.
• W1971953383 hasPublicationYear "1990" @default.
• W1971953383 type Work @default.
• W1971953383 sameAs 1971953383 @default.
• W1971953383 citedByCount "26" @default.
• W1971953383 countsByYear W19719533832012 @default.
• W1971953383 countsByYear W19719533832018 @default.
• W1971953383 countsByYear W19719533832019 @default.
• W1971953383 crossrefType "journal-article" @default.
• W1971953383 hasAuthorship W1971953383A5003228111 @default.
• W1971953383 hasAuthorship W1971953383A5016601391 @default.
• W1971953383 hasAuthorship W1971953383A5028282419 @default.
• W1971953383 hasAuthorship W1971953383A5051298410 @default.
• W1971953383 hasAuthorship W1971953383A5051614904 @default.
• W1971953383 hasAuthorship W1971953383A5070383859 @default.
• W1971953383 hasAuthorship W1971953383A5080256420 @default.
• W1971953383 hasConcept C104826730 @default.
• W1971953383 hasConcept C126322002 @default.
• W1971953383 hasConcept C134018914 @default.
• W1971953383 hasConcept C153911025 @default.
• W1971953383 hasConcept C159110408 @default.
• W1971953383 hasConcept C159654299 @default.
• W1971953383 hasConcept C170493617 @default.
• W1971953383 hasConcept C181199279 @default.
• W1971953383 hasConcept C203014093 @default.
• W1971953383 hasConcept C2775944032 @default.
• W1971953383 hasConcept C2777658100 @default.
• W1971953383 hasConcept C2777820912 @default.
• W1971953383 hasConcept C2780268870 @default.
• W1971953383 hasConcept C49453240 @default.
• W1971953383 hasConcept C502942594 @default.
• W1971953383 hasConcept C542903549 @default.
• W1971953383 hasConcept C54355233 @default.
• W1971953383 hasConcept C55493867 @default.
• W1971953383 hasConcept C64943373 @default.
• W1971953383 hasConcept C71924100 @default.
• W1971953383 hasConcept C81885089 @default.
• W1971953383 hasConcept C86803240 @default.
• W1971953383 hasConceptScore W1971953383C104826730 @default.
• W1971953383 hasConceptScore W1971953383C126322002 @default.
• W1971953383 hasConceptScore W1971953383C134018914 @default.
• W1971953383 hasConceptScore W1971953383C153911025 @default.
• W1971953383 hasConceptScore W1971953383C159110408 @default.
• W1971953383 hasConceptScore W1971953383C159654299 @default.
• W1971953383 hasConceptScore W1971953383C170493617 @default.
• W1971953383 hasConceptScore W1971953383C181199279 @default.
• W1971953383 hasConceptScore W1971953383C203014093 @default.
• W1971953383 hasConceptScore W1971953383C2775944032 @default.
• W1971953383 hasConceptScore W1971953383C2777658100 @default.
• W1971953383 hasConceptScore W1971953383C2777820912 @default.
• W1971953383 hasConceptScore W1971953383C2780268870 @default.
• W1971953383 hasConceptScore W1971953383C49453240 @default.
• W1971953383 hasConceptScore W1971953383C502942594 @default.
• W1971953383 hasConceptScore W1971953383C542903549 @default.
• W1971953383 hasConceptScore W1971953383C54355233 @default.
• W1971953383 hasConceptScore W1971953383C55493867 @default.
• W1971953383 hasConceptScore W1971953383C64943373 @default.
• W1971953383 hasConceptScore W1971953383C71924100 @default.
• W1971953383 hasConceptScore W1971953383C81885089 @default.

• next