FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971956967> ?p ?o ?g. }

• W1971956967 endingPage "325" @default.
• W1971956967 startingPage "313" @default.
• W1971956967 abstract "Ankrd2 may be a link between the sarcomere and the nucleus; a similar role has recently been proposed for CARP that has a high level of structural and functional conservation with Ankrd2. Both Ankrd2 and CARP are involved in striated muscle hypertrophy. The mechanism by which muscle stretch is sensed and signals are transduced is still unknown; however, Ankrd2 and CARP could play similar roles in pathways leading to hypertrophy, the triggering mechanisms being heart pressure overload monitored by CARP and mechanical stretch in skeletal muscle monitored by Ankrd2. Recently Ankrd2 and CARP have been proposed as members of a family of muscle ankyrin repeat proteins (MARPs) that form a complex with titin, myopalladin and calpain protease p94, involved in signaling and regulation of gene expression in response to muscle stress. Here, we show that Ankrd2 is able to interact with the Z-disc protein telethonin as well as being able to interact with three transcription factors: YB-1, PML and p53. Ankrd2 binding to the ubiquitous transcription factor YB-1 can be demonstrated both in vitro and in vivo; this is not very surprising, since a similar interaction was previously described for CARP. However, the interactions with PML and p53 are unexpected new findings, with interesting implications in the Ankrd2 signaling cascade. Ankrd2 co-localizes with the transcriptional co-activator and co-repressor PML in nuclear bodies (NBs) in human myoblasts as detected by confocal immunofluorescence. Interestingly, we show that Ankrd2 not only binds the tumor suppressor protein p53 both in vitro and in vivo but also enhances the up-regulation of the p21WAFI/CIPI promoter by p53. Therefore, our findings strengthen the hypothesis that Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation." @default.
• W1971956967 created "2016-06-24" @default.
• W1971956967 creator A5005828835 @default.
• W1971956967 creator A5012491473 @default.
• W1971956967 creator A5019416430 @default.
• W1971956967 creator A5040520731 @default.
• W1971956967 creator A5064789963 @default.
• W1971956967 creator A5070165519 @default.
• W1971956967 creator A5072332593 @default.
• W1971956967 creator A5077170451 @default.
• W1971956967 date "2004-05-01" @default.
• W1971956967 modified "2023-10-18" @default.
• W1971956967 title "The Ankrd2 Protein, a Link Between the Sarcomere and the Nucleus in Skeletal Muscle" @default.
• W1971956967 cites W1556421650 @default.
• W1971956967 cites W1774689153 @default.
• W1971956967 cites W1835642409 @default.
• W1971956967 cites W1964831428 @default.
• W1971956967 cites W1964832022 @default.
• W1971956967 cites W1964839574 @default.
• W1971956967 cites W1966485417 @default.
• W1971956967 cites W1970831361 @default.
• W1971956967 cites W1981897425 @default.
• W1971956967 cites W1987020830 @default.
• W1971956967 cites W1991712819 @default.
• W1971956967 cites W1992519649 @default.
• W1971956967 cites W1995380251 @default.
• W1971956967 cites W2011340042 @default.
• W1971956967 cites W2014873002 @default.
• W1971956967 cites W2015519364 @default.
• W1971956967 cites W2019448053 @default.
• W1971956967 cites W2022583515 @default.
• W1971956967 cites W2023033376 @default.
• W1971956967 cites W2027509505 @default.
• W1971956967 cites W2030297325 @default.
• W1971956967 cites W2039928165 @default.
• W1971956967 cites W2045198143 @default.
• W1971956967 cites W2046953920 @default.
• W1971956967 cites W2052651806 @default.
• W1971956967 cites W2066783138 @default.
• W1971956967 cites W2067046201 @default.
• W1971956967 cites W2067565043 @default.
• W1971956967 cites W2071245052 @default.
• W1971956967 cites W2071334751 @default.
• W1971956967 cites W2076149108 @default.
• W1971956967 cites W2077187719 @default.
• W1971956967 cites W2080073058 @default.
• W1971956967 cites W2083298529 @default.
• W1971956967 cites W2085058707 @default.
• W1971956967 cites W2088203536 @default.
• W1971956967 cites W2093567560 @default.
• W1971956967 cites W2095974846 @default.
• W1971956967 cites W2107575131 @default.
• W1971956967 cites W2115478217 @default.
• W1971956967 cites W2116717165 @default.
• W1971956967 cites W2121185454 @default.
• W1971956967 cites W2122703252 @default.
• W1971956967 cites W2129439677 @default.
• W1971956967 cites W2138282644 @default.
• W1971956967 cites W2138553198 @default.
• W1971956967 cites W2144284827 @default.
• W1971956967 cites W2148969043 @default.
• W1971956967 cites W2152697968 @default.
• W1971956967 cites W2154214785 @default.
• W1971956967 cites W2155311131 @default.
• W1971956967 cites W2166994240 @default.
• W1971956967 cites W2170693282 @default.
• W1971956967 cites W2335418691 @default.
• W1971956967 cites W2401958146 @default.
• W1971956967 cites W4213068446 @default.
• W1971956967 cites W4378632644 @default.
• W1971956967 doi "https://doi.org/10.1016/j.jmb.2004.03.071" @default.
• W1971956967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15136035" @default.
• W1971956967 hasPublicationYear "2004" @default.
• W1971956967 type Work @default.
• W1971956967 sameAs 1971956967 @default.
• W1971956967 citedByCount "136" @default.
• W1971956967 countsByYear W19719569672012 @default.
• W1971956967 countsByYear W19719569672013 @default.
• W1971956967 countsByYear W19719569672014 @default.
• W1971956967 countsByYear W19719569672015 @default.
• W1971956967 countsByYear W19719569672016 @default.
• W1971956967 countsByYear W19719569672017 @default.
• W1971956967 countsByYear W19719569672018 @default.
• W1971956967 countsByYear W19719569672019 @default.
• W1971956967 countsByYear W19719569672020 @default.
• W1971956967 countsByYear W19719569672021 @default.
• W1971956967 countsByYear W19719569672023 @default.
• W1971956967 crossrefType "journal-article" @default.
• W1971956967 hasAuthorship W1971956967A5005828835 @default.
• W1971956967 hasAuthorship W1971956967A5012491473 @default.
• W1971956967 hasAuthorship W1971956967A5019416430 @default.
• W1971956967 hasAuthorship W1971956967A5040520731 @default.
• W1971956967 hasAuthorship W1971956967A5064789963 @default.
• W1971956967 hasAuthorship W1971956967A5070165519 @default.
• W1971956967 hasAuthorship W1971956967A5072332593 @default.
• W1971956967 hasAuthorship W1971956967A5077170451 @default.
• W1971956967 hasConcept C104317684 @default.
• W1971956967 hasConcept C105702510 @default.

• next