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• W1971974512 abstract "Seasonally breeding mammals rely on the photoperiodic signal to restrict their fertility to a certain time of the year. The photoperiodic information is translated in the brain via the pineal hormone melatonin, and it is now well-established that it is the variation in the duration of the nocturnal peak of melatonin which synchronizes reproduction with the seasons. The Syrian hamster is a long day breeder, and sexual activity is therefore promoted by exposure to a long day photoperiod and inhibited by exposure to a short day photoperiod. Interestingly, in this species electrolytic lesion of the mediobasal hypothalamus abolishes the short day-induced gonadal regression. We have shown that the expression of a recently discovered neuronal population, namely RFamide-related peptide (rfrp) neurons, present in the mediobasal hypothalamus, is strongly down-regulated by melatonin in short day conditions, but not altered by circulating levels of sex steroids. The role of rfrp and its product RFRP-3 in the regulation of reproductive activity has been extensively studied in mammals, and our recent findings indicate that this peptide is a potent stimulator of the reproductive axis in the Syrian hamster. It induces a marked increase in GnRH neuron activity and gonadotropin secretion, and it is able to rescue reproductive activity in short day sexually inactive hamsters. Little is known about the localization of the RFRP-3 receptor, GPR147, in the rodent brain. Accumulating evidence suggests that RFRP-3 could be acting via two intermediates, the GnRH neurons in the preoptic area and the Kiss1 neurons in the arcuate nucleus, but future studies should aim at describing the localization of Gpr147 in the Syrian hamster brain. Altogether our data indicate that the rfrp neuronal population within the mediobasal hypothalamus might be a serious candidate in mediating the photoperiodic effects of melatonin on the regulation of the reproductive axis." @default.
• W1971974512 created "2016-06-24" @default.
• W1971974512 creator A5056487349 @default.
• W1971974512 creator A5077248676 @default.
• W1971974512 date "2012-01-01" @default.
• W1971974512 modified "2023-09-25" @default.
• W1971974512 title "RFRP neurons are critical gatekeepers for the photoperiodic control of reproduction" @default.
• W1971974512 cites W1508466752 @default.
• W1971974512 cites W1533247494 @default.
• W1971974512 cites W1540547666 @default.
• W1971974512 cites W1577822051 @default.
• W1971974512 cites W1895650277 @default.
• W1971974512 cites W1966997611 @default.
• W1971974512 cites W1970978037 @default.
• W1971974512 cites W1975045515 @default.
• W1971974512 cites W1980054843 @default.
• W1971974512 cites W1981297220 @default.
• W1971974512 cites W1981589604 @default.
• W1971974512 cites W1982481082 @default.
• W1971974512 cites W1982573687 @default.
• W1971974512 cites W1983141393 @default.
• W1971974512 cites W1983666444 @default.
• W1971974512 cites W1984995591 @default.
• W1971974512 cites W1988377203 @default.
• W1971974512 cites W1994157602 @default.
• W1971974512 cites W2003051826 @default.
• W1971974512 cites W2004119056 @default.
• W1971974512 cites W2007657953 @default.
• W1971974512 cites W2009424714 @default.
• W1971974512 cites W2012382894 @default.
• W1971974512 cites W2012822367 @default.
• W1971974512 cites W2014318642 @default.
• W1971974512 cites W2020281284 @default.
• W1971974512 cites W2024749335 @default.
• W1971974512 cites W2025414806 @default.
• W1971974512 cites W2027608196 @default.
• W1971974512 cites W2030898455 @default.
• W1971974512 cites W2033011212 @default.
• W1971974512 cites W2038039689 @default.
• W1971974512 cites W2041165166 @default.
• W1971974512 cites W2042450995 @default.
• W1971974512 cites W2055660125 @default.
• W1971974512 cites W2056832374 @default.
• W1971974512 cites W2058563831 @default.
• W1971974512 cites W2058782486 @default.
• W1971974512 cites W2062566674 @default.
• W1971974512 cites W2066166647 @default.
• W1971974512 cites W2066474185 @default.
• W1971974512 cites W2066627511 @default.
• W1971974512 cites W2069103915 @default.
• W1971974512 cites W2078526568 @default.
• W1971974512 cites W2081134805 @default.
• W1971974512 cites W2081993111 @default.
• W1971974512 cites W2084121053 @default.
• W1971974512 cites W2092053353 @default.
• W1971974512 cites W2093706999 @default.
• W1971974512 cites W2096274244 @default.
• W1971974512 cites W2098668493 @default.
• W1971974512 cites W2098917312 @default.
• W1971974512 cites W2100733933 @default.
• W1971974512 cites W2103204018 @default.
• W1971974512 cites W2103753396 @default.
• W1971974512 cites W2110912300 @default.
• W1971974512 cites W2111561559 @default.
• W1971974512 cites W2112319618 @default.
• W1971974512 cites W2113173524 @default.
• W1971974512 cites W2113887382 @default.
• W1971974512 cites W2115381325 @default.
• W1971974512 cites W2116806096 @default.
• W1971974512 cites W2119788961 @default.
• W1971974512 cites W2121637377 @default.
• W1971974512 cites W2125333644 @default.
• W1971974512 cites W2127199761 @default.
• W1971974512 cites W2130784408 @default.
• W1971974512 cites W2132956597 @default.
• W1971974512 cites W2139371826 @default.
• W1971974512 cites W2142686356 @default.
• W1971974512 cites W2143506157 @default.
• W1971974512 cites W2146027767 @default.
• W1971974512 cites W2149201295 @default.
• W1971974512 cites W2150149607 @default.
• W1971974512 cites W2153057301 @default.
• W1971974512 cites W2159663042 @default.
• W1971974512 cites W2161381885 @default.
• W1971974512 cites W2164425851 @default.
• W1971974512 cites W2164988522 @default.
• W1971974512 cites W2166025044 @default.
• W1971974512 cites W2167925490 @default.
• W1971974512 cites W2284615830 @default.
• W1971974512 cites W2418052745 @default.
• W1971974512 doi "https://doi.org/10.3389/fendo.2012.00168" @default.
• W1971974512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524517" @default.
• W1971974512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23264769" @default.
• W1971974512 hasPublicationYear "2012" @default.
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