FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971988052> ?p ?o ?g. }

• W1971988052 endingPage "1513" @default.
• W1971988052 startingPage "1505" @default.
• W1971988052 abstract "Phosphorylation of proteins on tyrosine residues is regulated by the activities of protein tyrosine kinases and protein tyrosine phosphatases. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) essentially and transiently expressed during development of the central and peripheral nervous systems. ALK has been identified as a major neuroblastoma predisposition gene and activating mutations have been identified in a subset of sporadic neuroblastoma tumors. We previously established that the mutated receptors were essentially retained in the endoplasmic reticulum/Golgi compartments due to their constitutive activity. Intriguingly we demonstrated a stronger phosphorylation for the minor pool of receptor addressed to the plasma membrane. We decided to investigate the potential involvement of tyrosine phosphatase in dephosphorylation of this intracellular pool. In this study we first showed that general inhibition of tyrosine phosphatases resulted in a dramatic increase of the tyrosine phosphorylation of the wild type but also of the mutated receptors. This increase not only required the intrinsic kinase activity of the ALK receptor but also involved the Src tyrosine kinase family. Second we provided strong evidences that the endoplasmic reticulum associated phosphatase PTP1B is key player in the control of ALK phosphorylation. Our data shed a new light on the biological significance of the basal phosphorylation levels of both wild type and mutated ALK receptors and could be essential to further understand their roles in malignancies." @default.
• W1971988052 created "2016-06-24" @default.
• W1971988052 creator A5001966222 @default.
• W1971988052 creator A5007653418 @default.
• W1971988052 creator A5023250460 @default.
• W1971988052 creator A5045337655 @default.
• W1971988052 creator A5051062120 @default.
• W1971988052 creator A5055549961 @default.
• W1971988052 creator A5077799920 @default.
• W1971988052 date "2013-06-01" @default.
• W1971988052 modified "2023-09-25" @default.
• W1971988052 title "Control of ALK (wild type and mutated forms) phosphorylation: Specific role of the phosphatase PTP1B" @default.
• W1971988052 cites W1897972509 @default.
• W1971988052 cites W1965204864 @default.
• W1971988052 cites W1969914656 @default.
• W1971988052 cites W1979107282 @default.
• W1971988052 cites W1981673694 @default.
• W1971988052 cites W1981714967 @default.
• W1971988052 cites W1992895077 @default.
• W1971988052 cites W2010978319 @default.
• W1971988052 cites W2012480312 @default.
• W1971988052 cites W2014639631 @default.
• W1971988052 cites W2022354436 @default.
• W1971988052 cites W2026002143 @default.
• W1971988052 cites W2035282066 @default.
• W1971988052 cites W2036161897 @default.
• W1971988052 cites W2038637004 @default.
• W1971988052 cites W2038665105 @default.
• W1971988052 cites W2040328392 @default.
• W1971988052 cites W2044558623 @default.
• W1971988052 cites W2060275730 @default.
• W1971988052 cites W2061278019 @default.
• W1971988052 cites W2061486885 @default.
• W1971988052 cites W2089296954 @default.
• W1971988052 cites W2104830962 @default.
• W1971988052 cites W2105699883 @default.
• W1971988052 cites W2107826507 @default.
• W1971988052 cites W2124478432 @default.
• W1971988052 cites W2126607341 @default.
• W1971988052 cites W2142188384 @default.
• W1971988052 doi "https://doi.org/10.1016/j.cellsig.2013.02.020" @default.
• W1971988052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23499906" @default.
• W1971988052 hasPublicationYear "2013" @default.
• W1971988052 type Work @default.
• W1971988052 sameAs 1971988052 @default.
• W1971988052 citedByCount "11" @default.
• W1971988052 countsByYear W19719880522014 @default.
• W1971988052 countsByYear W19719880522015 @default.
• W1971988052 countsByYear W19719880522016 @default.
• W1971988052 countsByYear W19719880522018 @default.
• W1971988052 countsByYear W19719880522019 @default.
• W1971988052 countsByYear W19719880522021 @default.
• W1971988052 countsByYear W19719880522022 @default.
• W1971988052 crossrefType "journal-article" @default.
• W1971988052 hasAuthorship W1971988052A5001966222 @default.
• W1971988052 hasAuthorship W1971988052A5007653418 @default.
• W1971988052 hasAuthorship W1971988052A5023250460 @default.
• W1971988052 hasAuthorship W1971988052A5045337655 @default.
• W1971988052 hasAuthorship W1971988052A5051062120 @default.
• W1971988052 hasAuthorship W1971988052A5055549961 @default.
• W1971988052 hasAuthorship W1971988052A5077799920 @default.
• W1971988052 hasConcept C101544691 @default.
• W1971988052 hasConcept C108636557 @default.
• W1971988052 hasConcept C11960822 @default.
• W1971988052 hasConcept C170493617 @default.
• W1971988052 hasConcept C180361614 @default.
• W1971988052 hasConcept C23440912 @default.
• W1971988052 hasConcept C2775960820 @default.
• W1971988052 hasConcept C2777553839 @default.
• W1971988052 hasConcept C42362537 @default.
• W1971988052 hasConcept C502942594 @default.
• W1971988052 hasConcept C55493867 @default.
• W1971988052 hasConcept C62478195 @default.
• W1971988052 hasConcept C85528070 @default.
• W1971988052 hasConcept C86803240 @default.
• W1971988052 hasConcept C95444343 @default.
• W1971988052 hasConceptScore W1971988052C101544691 @default.
• W1971988052 hasConceptScore W1971988052C108636557 @default.
• W1971988052 hasConceptScore W1971988052C11960822 @default.
• W1971988052 hasConceptScore W1971988052C170493617 @default.
• W1971988052 hasConceptScore W1971988052C180361614 @default.
• W1971988052 hasConceptScore W1971988052C23440912 @default.
• W1971988052 hasConceptScore W1971988052C2775960820 @default.
• W1971988052 hasConceptScore W1971988052C2777553839 @default.
• W1971988052 hasConceptScore W1971988052C42362537 @default.
• W1971988052 hasConceptScore W1971988052C502942594 @default.
• W1971988052 hasConceptScore W1971988052C55493867 @default.
• W1971988052 hasConceptScore W1971988052C62478195 @default.
• W1971988052 hasConceptScore W1971988052C85528070 @default.
• W1971988052 hasConceptScore W1971988052C86803240 @default.
• W1971988052 hasConceptScore W1971988052C95444343 @default.
• W1971988052 hasIssue "6" @default.
• W1971988052 hasLocation W19719880521 @default.
• W1971988052 hasLocation W19719880522 @default.
• W1971988052 hasLocation W19719880523 @default.
• W1971988052 hasLocation W19719880524 @default.
• W1971988052 hasOpenAccess W1971988052 @default.
• W1971988052 hasPrimaryLocation W19719880521 @default.

• next