Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971990167> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1971990167 abstract "Dopamine metabolism in vivo was studied after treatment with piflutixol (6-fluoro-9-[3-(4-(2-hydroxyethyl)piperidino)propylidene]-2-trifluoromethyl-thioxanthene) a novel thioxanthene derivative with potent neuroleptic properties and sedative effects. In mice piflutixol increased both noradrenaline (NA) and dopamine (DA) turnover rate measured as increased disappearance of 14C-amines formed from 14C-L-tyrosine. The ratio between the minimal effective doses for 14C-NA and 14C-DA disappearance was 2, which is of the same order of magnitude as obtained with cis(Z)-chlorprothixene, pimozide and chlorpromazine. After 14C-L-tyrosine the accumulation of 14C-dopamine was initially increased after which it decreased from day 4--5. These changes resemble those obtained after other neuroleptics and parallel the initial receptor blockade and the subsequent receptor supersensitivity found in pharmacological experiments (MOLLER NIELSEN et al. 1977). Piflutixol induced a rapid increase in both DOPAC and HVA with a maximal effect after 2--6 hours. After 2--3 days the levels had returned to normal. The doses of piflutixol which at 24 hours doubled the levels of DOPAC and HVA were found to be 0.055 and 0.021 mg/kg subcutaneously, respectively. It is concluded that piflutixol is a powerful and long lasting DA receptor blocking agent, which changes the synthesis and release of DA in a way similar to basic neuroleptics." @default.
- W1971990167 created "2016-06-24" @default.
- W1971990167 creator A5043710094 @default.
- W1971990167 date "2009-03-13" @default.
- W1971990167 modified "2023-09-26" @default.
- W1971990167 title "Effect of Piflutixol on Turnover of Catecholamines in Mouse Brain and Rat Corpus Striatum" @default.
- W1971990167 cites W1969168387 @default.
- W1971990167 cites W1984938103 @default.
- W1971990167 cites W2013718093 @default.
- W1971990167 cites W2025081012 @default.
- W1971990167 cites W2057884674 @default.
- W1971990167 cites W2073305149 @default.
- W1971990167 cites W2093718431 @default.
- W1971990167 cites W2097978353 @default.
- W1971990167 cites W2110894929 @default.
- W1971990167 cites W2138826416 @default.
- W1971990167 cites W2159996636 @default.
- W1971990167 doi "https://doi.org/10.1111/j.1600-0773.1977.tb02155.x" @default.
- W1971990167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/579556" @default.
- W1971990167 hasPublicationYear "2009" @default.
- W1971990167 type Work @default.
- W1971990167 sameAs 1971990167 @default.
- W1971990167 citedByCount "4" @default.
- W1971990167 crossrefType "journal-article" @default.
- W1971990167 hasAuthorship W1971990167A5043710094 @default.
- W1971990167 hasConcept C120069818 @default.
- W1971990167 hasConcept C126322002 @default.
- W1971990167 hasConcept C134018914 @default.
- W1971990167 hasConcept C150903083 @default.
- W1971990167 hasConcept C170493617 @default.
- W1971990167 hasConcept C185592680 @default.
- W1971990167 hasConcept C207001950 @default.
- W1971990167 hasConcept C2777845345 @default.
- W1971990167 hasConcept C2778775820 @default.
- W1971990167 hasConcept C2780062018 @default.
- W1971990167 hasConcept C2780948584 @default.
- W1971990167 hasConcept C513476851 @default.
- W1971990167 hasConcept C55493867 @default.
- W1971990167 hasConcept C71924100 @default.
- W1971990167 hasConcept C86803240 @default.
- W1971990167 hasConcept C98274493 @default.
- W1971990167 hasConceptScore W1971990167C120069818 @default.
- W1971990167 hasConceptScore W1971990167C126322002 @default.
- W1971990167 hasConceptScore W1971990167C134018914 @default.
- W1971990167 hasConceptScore W1971990167C150903083 @default.
- W1971990167 hasConceptScore W1971990167C170493617 @default.
- W1971990167 hasConceptScore W1971990167C185592680 @default.
- W1971990167 hasConceptScore W1971990167C207001950 @default.
- W1971990167 hasConceptScore W1971990167C2777845345 @default.
- W1971990167 hasConceptScore W1971990167C2778775820 @default.
- W1971990167 hasConceptScore W1971990167C2780062018 @default.
- W1971990167 hasConceptScore W1971990167C2780948584 @default.
- W1971990167 hasConceptScore W1971990167C513476851 @default.
- W1971990167 hasConceptScore W1971990167C55493867 @default.
- W1971990167 hasConceptScore W1971990167C71924100 @default.
- W1971990167 hasConceptScore W1971990167C86803240 @default.
- W1971990167 hasConceptScore W1971990167C98274493 @default.
- W1971990167 hasLocation W19719901671 @default.
- W1971990167 hasLocation W19719901672 @default.
- W1971990167 hasOpenAccess W1971990167 @default.
- W1971990167 hasPrimaryLocation W19719901671 @default.
- W1971990167 hasRelatedWork W117235360 @default.
- W1971990167 hasRelatedWork W1971086779 @default.
- W1971990167 hasRelatedWork W1984070948 @default.
- W1971990167 hasRelatedWork W2000307967 @default.
- W1971990167 hasRelatedWork W2017744422 @default.
- W1971990167 hasRelatedWork W2056123374 @default.
- W1971990167 hasRelatedWork W2079458258 @default.
- W1971990167 hasRelatedWork W2086798733 @default.
- W1971990167 hasRelatedWork W2415652262 @default.
- W1971990167 hasRelatedWork W2980659257 @default.
- W1971990167 isParatext "false" @default.
- W1971990167 isRetracted "false" @default.
- W1971990167 magId "1971990167" @default.
- W1971990167 workType "article" @default.