FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971994497> ?p ?o ?g. }

• W1971994497 endingPage "2034" @default.
• W1971994497 startingPage "2027" @default.
• W1971994497 abstract "Disruption of the blood-brain barrier (BBB) and subsequent brain edema are major contributors to the pathogenesis of ischemic stroke, however, current clinical therapeutic methods remains unsatisfactory. Electroacupuncture (EA) pretreatment has a protective effect against cerebral ischemia/reperfusion (I/R). However, the underlying mechanisms remain to be fully elucidated. In the present study, the effect of EA pretreatment on BBB disruption was investigated in a focal I/R rat model. Male Sprague-Dawley rats (280-320 g) were pretreated with EA at the acupoint 'Baihui' (GV20) 30 min/day, for five days consecutively prior to focal cerebral I/R, which was induced by middle cerebral artery occlusion (MCAO) for 2 h. The results demonstrated that the infarction volume, brain water content and neurological deficits increased in the MCAO model rats at 3 h and 24 h post-reperfusion, and were attenuated significantly by EA pretreatment. Furthermore, electron microscopy examination confirmed a reduction in brain edema reduction in the EA pretreated rats. Western blot analysis revealed that the tight junction proteins between endothelial cells, including claudin-5, occludin, were significantly degraded, while the protein expression of phosphorylated (p-)caveolin-1 and p-Akt increased following reperfusion, all of which were alleviated by EA pretreatment. However, no significant differences were observed in the expression of caveolin-1 or Akt. Overall, the results demonstrated that EA pretreatment significantly reduced BBB permeability and brain edema, which were correlated with alleviation of the degradation of tight junction proteins and inhibition of the expression of p-caveolin-1 in the endothelial cells." @default.
• W1971994497 created "2016-06-24" @default.
• W1971994497 creator A5030754847 @default.
• W1971994497 creator A5037872294 @default.
• W1971994497 creator A5079528011 @default.
• W1971994497 date "2015-04-23" @default.
• W1971994497 modified "2023-10-01" @default.
• W1971994497 title "Electroacupuncture pretreatment attenuates blood-brain barrier disruption following cerebral ischemia/reperfusion" @default.
• W1971994497 cites W128151115 @default.
• W1971994497 cites W1523932090 @default.
• W1971994497 cites W1557888154 @default.
• W1971994497 cites W1796054280 @default.
• W1971994497 cites W1988086690 @default.
• W1971994497 cites W1992758695 @default.
• W1971994497 cites W1997044174 @default.
• W1971994497 cites W2005072188 @default.
• W1971994497 cites W2006959635 @default.
• W1971994497 cites W2019862207 @default.
• W1971994497 cites W2022219828 @default.
• W1971994497 cites W2023820003 @default.
• W1971994497 cites W2038519029 @default.
• W1971994497 cites W2070940233 @default.
• W1971994497 cites W2103741737 @default.
• W1971994497 cites W2103831817 @default.
• W1971994497 cites W2104567497 @default.
• W1971994497 cites W2104832976 @default.
• W1971994497 cites W2107689425 @default.
• W1971994497 cites W2108548668 @default.
• W1971994497 cites W2112505121 @default.
• W1971994497 cites W2113481537 @default.
• W1971994497 cites W2118309500 @default.
• W1971994497 cites W2130639482 @default.
• W1971994497 cites W2132500820 @default.
• W1971994497 cites W2145881880 @default.
• W1971994497 cites W2151262021 @default.
• W1971994497 cites W2159590405 @default.
• W1971994497 cites W2169645346 @default.
• W1971994497 cites W2792583460 @default.
• W1971994497 doi "https://doi.org/10.3892/mmr.2015.3672" @default.
• W1971994497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25936438" @default.
• W1971994497 hasPublicationYear "2015" @default.
• W1971994497 type Work @default.
• W1971994497 sameAs 1971994497 @default.
• W1971994497 citedByCount "27" @default.
• W1971994497 countsByYear W19719944972016 @default.
• W1971994497 countsByYear W19719944972017 @default.
• W1971994497 countsByYear W19719944972018 @default.
• W1971994497 countsByYear W19719944972019 @default.
• W1971994497 countsByYear W19719944972020 @default.
• W1971994497 countsByYear W19719944972021 @default.
• W1971994497 countsByYear W19719944972022 @default.
• W1971994497 countsByYear W19719944972023 @default.
• W1971994497 crossrefType "journal-article" @default.
• W1971994497 hasAuthorship W1971994497A5030754847 @default.
• W1971994497 hasAuthorship W1971994497A5037872294 @default.
• W1971994497 hasAuthorship W1971994497A5079528011 @default.
• W1971994497 hasBestOaLocation W19719944971 @default.
• W1971994497 hasConcept C104317684 @default.
• W1971994497 hasConcept C126322002 @default.
• W1971994497 hasConcept C142724271 @default.
• W1971994497 hasConcept C177779419 @default.
• W1971994497 hasConcept C185592680 @default.
• W1971994497 hasConcept C190283241 @default.
• W1971994497 hasConcept C204787440 @default.
• W1971994497 hasConcept C2775962179 @default.
• W1971994497 hasConcept C2776202274 @default.
• W1971994497 hasConcept C2776415932 @default.
• W1971994497 hasConcept C2777649898 @default.
• W1971994497 hasConcept C2778402981 @default.
• W1971994497 hasConcept C2780114680 @default.
• W1971994497 hasConcept C2780870201 @default.
• W1971994497 hasConcept C2780886150 @default.
• W1971994497 hasConcept C42219234 @default.
• W1971994497 hasConcept C529278444 @default.
• W1971994497 hasConcept C541997718 @default.
• W1971994497 hasConcept C55493867 @default.
• W1971994497 hasConcept C56837625 @default.
• W1971994497 hasConcept C71924100 @default.
• W1971994497 hasConcept C75217442 @default.
• W1971994497 hasConcept C98274493 @default.
• W1971994497 hasConceptScore W1971994497C104317684 @default.
• W1971994497 hasConceptScore W1971994497C126322002 @default.
• W1971994497 hasConceptScore W1971994497C142724271 @default.
• W1971994497 hasConceptScore W1971994497C177779419 @default.
• W1971994497 hasConceptScore W1971994497C185592680 @default.
• W1971994497 hasConceptScore W1971994497C190283241 @default.
• W1971994497 hasConceptScore W1971994497C204787440 @default.
• W1971994497 hasConceptScore W1971994497C2775962179 @default.
• W1971994497 hasConceptScore W1971994497C2776202274 @default.
• W1971994497 hasConceptScore W1971994497C2776415932 @default.
• W1971994497 hasConceptScore W1971994497C2777649898 @default.
• W1971994497 hasConceptScore W1971994497C2778402981 @default.
• W1971994497 hasConceptScore W1971994497C2780114680 @default.
• W1971994497 hasConceptScore W1971994497C2780870201 @default.
• W1971994497 hasConceptScore W1971994497C2780886150 @default.
• W1971994497 hasConceptScore W1971994497C42219234 @default.
• W1971994497 hasConceptScore W1971994497C529278444 @default.
• W1971994497 hasConceptScore W1971994497C541997718 @default.

• next