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- W1972004339 endingPage "154" @default.
- W1972004339 startingPage "127" @default.
- W1972004339 abstract "Human tumors express high levels of growth factors and their receptors, and many types of malignant cells appear to exhibit autocrine- or paracrine-stimulated growth. Therefore, antireceptor directed therapies have the potential of being useful anti-cancer agents. A series of murine monoclonal antibodies (MAbs) directed against human growth factor receptors and their corresponding growth factors have been produced. MAbs against the receptors for epidermal growth factor, Her2/Neu, transferrin, insulin-like growth factor, interleukin, (IL)-2 and IL-1 are currently being evaluated. MAbs directed against epidermal growth factor, transforming growth factor-alpha, bombesin, IL-2, and IL-6 also are under study. These MAbs have shown promising preclinical activity, and some of them are being tested in clinical trials. So far, anti-tumor responses have been observed with anti-IL-2 receptor, anti-bombesin and anti-IL-6 MAbs. Further research is focusing in the production of chimeric and humanized MAbs, in order to obviate the problem of host immune reactions." @default.
- W1972004339 created "2016-06-24" @default.
- W1972004339 creator A5043787919 @default.
- W1972004339 creator A5077979726 @default.
- W1972004339 date "1994-01-01" @default.
- W1972004339 modified "2023-10-18" @default.
- W1972004339 title "Receptor blockade with monoclomal antibodies as anti-cancer therapy" @default.
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