FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972017483> ?p ?o ?g. }

• W1972017483 endingPage "e70456" @default.
• W1972017483 startingPage "e70456" @default.
• W1972017483 abstract "Gap junctions formed by two hemichannels from two neighboring cells are cell-to-cell communication channels; hemichannels are communication channels between intracellular and extracellular environments. Hemichannels are hexameric proteins formed by connexins, pannexins, innexins and vinnexins. Innexin-hemichannels (innexons) exist in the lepidopteran cell surface, but their component innexins and functions have not been reported. Recent studies by others have demonstrated that hemichannels, connexons and pannexons from vertebrates serve as regulators of apoptosis via inactivating the PI3K/Akt signaling pathway. Here, the apoptogenic properties of innexons are demonstrated using two innexin cDNAs, Spli-inx2 and Spli-inx3, which were isolated from hemocytes of lepidopteran Spodoptera litura. Alignment analysis revealed that these two genes belong to a conserved innexin family, as they contain the insect signature YYQWV motif at the beginning of the second transmembrane domain. Immunofluorescence showed that two fusion proteins, Inx2-V5 and Inx3-V5, were localized predominantly in the cell membrane, cytoplasm and also nuclei. Ectopic expression in Sf9 cells and over-expression of Inx2 and Inx3 in Spli221 cells promoted apoptosis. In the Spli221 cells, apoptotic cells presented remarkable membrane blebbing. This study also showed that Sf9 and Spli221 cells undergo low level apoptosis under normal culture conditions, but not Hi5 cells. In Hi5 stable cell lines, biotinylation was used to isolate surface proteins and confirm Inx2 and Inx3 localization in the cell membrane and also further data showed that Hi5 cells may activate the PI3K signaling pathway via phosphorylating molecular Akt downstream. This result suggests that innexon-promoted apoptosis may be involving the PI3K/Akt signaling pathway. These findings will facilitate further examinations of the apoptotic regulation by the PI3K/Akt signaling pathway and comparative studies of innexons, connexons, pannexons, and vinnexons." @default.
• W1972017483 created "2016-06-24" @default.
• W1972017483 creator A5021384155 @default.
• W1972017483 creator A5029348144 @default.
• W1972017483 creator A5030054597 @default.
• W1972017483 creator A5030656057 @default.
• W1972017483 creator A5049692788 @default.
• W1972017483 creator A5066579736 @default.
• W1972017483 creator A5072963277 @default.
• W1972017483 date "2013-07-30" @default.
• W1972017483 modified "2023-10-11" @default.
• W1972017483 title "A Role for Innexin2 and Innexin3 Proteins from Spodoptera litura in Apoptosis" @default.
• W1972017483 cites W1563442275 @default.
• W1972017483 cites W1634736267 @default.
• W1972017483 cites W1966125735 @default.
• W1972017483 cites W1983460238 @default.
• W1972017483 cites W1990424793 @default.
• W1972017483 cites W1991139188 @default.
• W1972017483 cites W1992295760 @default.
• W1972017483 cites W1995283361 @default.
• W1972017483 cites W1996543066 @default.
• W1972017483 cites W1996964798 @default.
• W1972017483 cites W2007057690 @default.
• W1972017483 cites W2010088414 @default.
• W1972017483 cites W2011064394 @default.
• W1972017483 cites W2014669864 @default.
• W1972017483 cites W2017588225 @default.
• W1972017483 cites W2019310006 @default.
• W1972017483 cites W2034357381 @default.
• W1972017483 cites W2036376383 @default.
• W1972017483 cites W2038477045 @default.
• W1972017483 cites W2043879567 @default.
• W1972017483 cites W2045092834 @default.
• W1972017483 cites W2047803867 @default.
• W1972017483 cites W2054022334 @default.
• W1972017483 cites W2054648838 @default.
• W1972017483 cites W2071769324 @default.
• W1972017483 cites W2072622802 @default.
• W1972017483 cites W2080413710 @default.
• W1972017483 cites W2080735778 @default.
• W1972017483 cites W2081871112 @default.
• W1972017483 cites W2092850219 @default.
• W1972017483 cites W2125797569 @default.
• W1972017483 cites W2138977093 @default.
• W1972017483 cites W2156441452 @default.
• W1972017483 cites W2161164095 @default.
• W1972017483 cites W2161930006 @default.
• W1972017483 cites W2170229697 @default.
• W1972017483 cites W2170730572 @default.
• W1972017483 cites W4211096124 @default.
• W1972017483 doi "https://doi.org/10.1371/journal.pone.0070456" @default.
• W1972017483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3728205" @default.
• W1972017483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936205" @default.
• W1972017483 hasPublicationYear "2013" @default.
• W1972017483 type Work @default.
• W1972017483 sameAs 1972017483 @default.
• W1972017483 citedByCount "27" @default.
• W1972017483 countsByYear W19720174832014 @default.
• W1972017483 countsByYear W19720174832015 @default.
• W1972017483 countsByYear W19720174832016 @default.
• W1972017483 countsByYear W19720174832017 @default.
• W1972017483 countsByYear W19720174832018 @default.
• W1972017483 countsByYear W19720174832019 @default.
• W1972017483 countsByYear W19720174832020 @default.
• W1972017483 countsByYear W19720174832021 @default.
• W1972017483 countsByYear W19720174832022 @default.
• W1972017483 countsByYear W19720174832023 @default.
• W1972017483 crossrefType "journal-article" @default.
• W1972017483 hasAuthorship W1972017483A5021384155 @default.
• W1972017483 hasAuthorship W1972017483A5029348144 @default.
• W1972017483 hasAuthorship W1972017483A5030054597 @default.
• W1972017483 hasAuthorship W1972017483A5030656057 @default.
• W1972017483 hasAuthorship W1972017483A5049692788 @default.
• W1972017483 hasAuthorship W1972017483A5066579736 @default.
• W1972017483 hasAuthorship W1972017483A5072963277 @default.
• W1972017483 hasBestOaLocation W19720174831 @default.
• W1972017483 hasConcept C103878061 @default.
• W1972017483 hasConcept C104317684 @default.
• W1972017483 hasConcept C127992366 @default.
• W1972017483 hasConcept C153911025 @default.
• W1972017483 hasConcept C158157758 @default.
• W1972017483 hasConcept C173758957 @default.
• W1972017483 hasConcept C190062978 @default.
• W1972017483 hasConcept C190283241 @default.
• W1972017483 hasConcept C201685922 @default.
• W1972017483 hasConcept C2776273252 @default.
• W1972017483 hasConcept C2777773057 @default.
• W1972017483 hasConcept C2780228694 @default.
• W1972017483 hasConcept C40767141 @default.
• W1972017483 hasConcept C55493867 @default.
• W1972017483 hasConcept C59822182 @default.
• W1972017483 hasConcept C62478195 @default.
• W1972017483 hasConcept C75217442 @default.
• W1972017483 hasConcept C79879829 @default.
• W1972017483 hasConcept C86554907 @default.
• W1972017483 hasConcept C86803240 @default.
• W1972017483 hasConcept C95444343 @default.
• W1972017483 hasConceptScore W1972017483C103878061 @default.

• next