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- W1972019417 abstract "Abstract Betazole, (β-(3-pyrazolyl)-ethylammonium), a very weak H2-receptor agonist of histamine is compared, in the semiempirical quantum chemical CNDO/2 approximation, to histamine. The molecular determinants responsible for the H2-activity, such as the conformation of the ethylammonium side chain, a negative global charge on the imidazole ring, the existence of a proton on the N-terminal, as well as the inversion of the tautomeric preference for the cationic and neutral forms are considered. It was determined that betazole fulfilled all of the above except for the tautomerism N3-H→N1-H. It is concluded that the proton transfer from N3 to N1 is an important and necessary step in the mechanism of action of the H2-receptor agonists of histamine." @default.
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- W1972019417 date "1989-08-01" @default.
- W1972019417 modified "2023-09-26" @default.
- W1972019417 title "Étude comparative CNDO/2 des déterminants moléculaires de l'activité agoniste de récepteur-H2 dans l'histamine et le bétazol" @default.
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- W1972019417 doi "https://doi.org/10.1016/0223-5234(89)90085-8" @default.
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