FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972021972> ?p ?o ?g. }

• W1972021972 endingPage "343" @default.
• W1972021972 startingPage "333" @default.
• W1972021972 abstract "Tumor cells traverse the basement membrane zone and gain access to the underlying mesenchyme to eventually form metastases. Laminin 5 is a major component of the basement membrane and connects keratinocytes at the level of hemidesmosomes to the mesenchyme. Underneath invading tumor cells anti-laminin 5 staining is diminished, and laminin 5 degradation products can stimulate cell migration and epidermal growth factor (EGF) receptor signaling. To investigate laminin 5 expression in parental HaCaT and tumorigenic c-Ha-ras-transformed HaCaT II-4rt keratinocytes, the cells were cultivated under monolayer and organotypic culture conditions. In monolayer cultures, HaCaT and c-Ha-ras-transformed HaCaT II-4rt keratinocytes secreted comparable amounts of laminin 5. After 7 days of organotypic cultures, collagen IV, beta4-integrin, nidogen and laminin 5 were detected along the epithelial-mesenchymal interface of parental HaCaT keratinocytes, while staining for these proteins was patchy or absent in the organotypic cultures with c-Ha-ras-transformed HaCaT II-4rt cells. Immunoblotting analysis confirmed absence of laminin 5 deposition in organotypic cultures of c-Ha-ras-transformed HaCaT II-4rt while the protein was detected in organotypic cultures of HaCaT keratinocytes. Surprisingly, however, the alpha3 and gamma2 laminin chain transcripts were strongly induced in c-Ha-ras-transformed HaCaT II-4rt cells by organotypic culture conditions, indicating that invasive epidermal tumor cells retain high mRNA levels for laminin 5 chains and suggesting an autocrine/paracrine induction of the laminin chain mRNAs. Moreover, as laminin 5 was absent in organotypic cultures of c-Ha-ras-transformed HaCaT II-4rt cells, it suggests immediate degradation of the protein. Degradation products may further contribute to the malignant phenotype by enhancing cellular migration and EGF-receptor activation." @default.
• W1972021972 created "2016-06-24" @default.
• W1972021972 creator A5009777601 @default.
• W1972021972 creator A5021209261 @default.
• W1972021972 creator A5057806385 @default.
• W1972021972 creator A5078749744 @default.
• W1972021972 date "2006-05-01" @default.
• W1972021972 modified "2023-09-27" @default.
• W1972021972 title "Expression of laminin 5 by parental and c-Ha-ras-transformed HaCaT keratinocytes in organotypic cultures" @default.
• W1972021972 cites W1496520030 @default.
• W1972021972 cites W1525660436 @default.
• W1972021972 cites W1656339735 @default.
• W1972021972 cites W1968147913 @default.
• W1972021972 cites W1969482526 @default.
• W1972021972 cites W1970559721 @default.
• W1972021972 cites W1978837916 @default.
• W1972021972 cites W1984664175 @default.
• W1972021972 cites W1987408667 @default.
• W1972021972 cites W1994847835 @default.
• W1972021972 cites W1995704830 @default.
• W1972021972 cites W2004626124 @default.
• W1972021972 cites W2009568983 @default.
• W1972021972 cites W2013099472 @default.
• W1972021972 cites W2014966587 @default.
• W1972021972 cites W2018083717 @default.
• W1972021972 cites W2026988153 @default.
• W1972021972 cites W2027950070 @default.
• W1972021972 cites W2032879380 @default.
• W1972021972 cites W2045702433 @default.
• W1972021972 cites W2052801013 @default.
• W1972021972 cites W2053197957 @default.
• W1972021972 cites W2054594987 @default.
• W1972021972 cites W2055870465 @default.
• W1972021972 cites W2067999123 @default.
• W1972021972 cites W2070053893 @default.
• W1972021972 cites W2070292028 @default.
• W1972021972 cites W2075285486 @default.
• W1972021972 cites W2076394185 @default.
• W1972021972 cites W2082677148 @default.
• W1972021972 cites W2083012075 @default.
• W1972021972 cites W2092200803 @default.
• W1972021972 cites W2092896554 @default.
• W1972021972 cites W2094119300 @default.
• W1972021972 cites W2107748997 @default.
• W1972021972 cites W2121513486 @default.
• W1972021972 cites W2124389355 @default.
• W1972021972 cites W2125117783 @default.
• W1972021972 cites W2130709112 @default.
• W1972021972 cites W2130785585 @default.
• W1972021972 cites W2136558537 @default.
• W1972021972 cites W2140273413 @default.
• W1972021972 cites W2143464311 @default.
• W1972021972 cites W2147915516 @default.
• W1972021972 cites W2155021601 @default.
• W1972021972 cites W2167970431 @default.
• W1972021972 cites W2169606620 @default.
• W1972021972 cites W4294216491 @default.
• W1972021972 cites W85666087 @default.
• W1972021972 doi "https://doi.org/10.1016/j.ejcb.2005.12.002" @default.
• W1972021972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16460839" @default.
• W1972021972 hasPublicationYear "2006" @default.
• W1972021972 type Work @default.
• W1972021972 sameAs 1972021972 @default.
• W1972021972 citedByCount "3" @default.
• W1972021972 countsByYear W19720219722013 @default.
• W1972021972 crossrefType "journal-article" @default.
• W1972021972 hasAuthorship W1972021972A5009777601 @default.
• W1972021972 hasAuthorship W1972021972A5021209261 @default.
• W1972021972 hasAuthorship W1972021972A5057806385 @default.
• W1972021972 hasAuthorship W1972021972A5078749744 @default.
• W1972021972 hasConcept C118995209 @default.
• W1972021972 hasConcept C147075424 @default.
• W1972021972 hasConcept C1491633281 @default.
• W1972021972 hasConcept C153911025 @default.
• W1972021972 hasConcept C185592680 @default.
• W1972021972 hasConcept C189165786 @default.
• W1972021972 hasConcept C195687474 @default.
• W1972021972 hasConcept C2776193487 @default.
• W1972021972 hasConcept C2777074287 @default.
• W1972021972 hasConcept C2778608917 @default.
• W1972021972 hasConcept C2779814568 @default.
• W1972021972 hasConcept C54355233 @default.
• W1972021972 hasConcept C55493867 @default.
• W1972021972 hasConcept C81885089 @default.
• W1972021972 hasConcept C86803240 @default.
• W1972021972 hasConcept C95444343 @default.
• W1972021972 hasConceptScore W1972021972C118995209 @default.
• W1972021972 hasConceptScore W1972021972C147075424 @default.
• W1972021972 hasConceptScore W1972021972C1491633281 @default.
• W1972021972 hasConceptScore W1972021972C153911025 @default.
• W1972021972 hasConceptScore W1972021972C185592680 @default.
• W1972021972 hasConceptScore W1972021972C189165786 @default.
• W1972021972 hasConceptScore W1972021972C195687474 @default.
• W1972021972 hasConceptScore W1972021972C2776193487 @default.
• W1972021972 hasConceptScore W1972021972C2777074287 @default.
• W1972021972 hasConceptScore W1972021972C2778608917 @default.
• W1972021972 hasConceptScore W1972021972C2779814568 @default.
• W1972021972 hasConceptScore W1972021972C54355233 @default.

• next