Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972027498> ?p ?o ?g. }
- W1972027498 endingPage "973" @default.
- W1972027498 startingPage "966" @default.
- W1972027498 abstract "Hydroxybutyrylcarnitine (HB-carnitine) is a metabolite that has been associated with insulin resistance and type 2 diabetes mellitus. It is currently unknown whether HB-carnitine can be produced from D-3-hydroxybutyrate (D-3HB), a ketone body; but its formation from L-3-HB-CoA, a fatty acid β-oxidation intermediate, is well established. We aimed to assess which stereoisomers of 3-HB-carnitine are present in vivo. Ketosis and increased fatty acid oxidation were induced in 12 lean healthy men by a 38-hour fasting period. The D-3HB kinetics (stable isotope technique) and stereoisomers of muscle 3-HB-carnitine (high-performance liquid chromatography/ultra-performance liquid chromatography-tandem mass spectrometry) were measured. Muscle D-3HB-carnitine content was much higher compared with L-3HB-carnitine. In addition, muscle D-3HB-carnitine correlated significantly with D-3-HB production. Following the finding that a ketone body can be converted into a carnitine ester in vivo, we show in vitro that D-3-HB can be converted into HB-carnitine (ketocarnitine) via an acyl-CoA synthetase reaction in several tissues including human muscle. During fasting, HB-carnitine in muscle is derived mainly from the ketone body D-3HB. The role of D-3HB-carnitine synthesis in metabolism remains to be elucidated." @default.
- W1972027498 created "2016-06-24" @default.
- W1972027498 creator A5010029482 @default.
- W1972027498 creator A5020357107 @default.
- W1972027498 creator A5027726446 @default.
- W1972027498 creator A5040743356 @default.
- W1972027498 creator A5040790993 @default.
- W1972027498 creator A5052423373 @default.
- W1972027498 creator A5053378507 @default.
- W1972027498 creator A5063050485 @default.
- W1972027498 creator A5066470222 @default.
- W1972027498 creator A5082493161 @default.
- W1972027498 creator A5087611764 @default.
- W1972027498 date "2012-07-01" @default.
- W1972027498 modified "2023-10-15" @default.
- W1972027498 title "Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite" @default.
- W1972027498 cites W1834811765 @default.
- W1972027498 cites W1966137634 @default.
- W1972027498 cites W1967600689 @default.
- W1972027498 cites W1983469797 @default.
- W1972027498 cites W1988632024 @default.
- W1972027498 cites W1988719729 @default.
- W1972027498 cites W1995392322 @default.
- W1972027498 cites W2001158336 @default.
- W1972027498 cites W2006689411 @default.
- W1972027498 cites W2023929783 @default.
- W1972027498 cites W2025243002 @default.
- W1972027498 cites W2047448684 @default.
- W1972027498 cites W2048362477 @default.
- W1972027498 cites W2055653312 @default.
- W1972027498 cites W2060669952 @default.
- W1972027498 cites W2063278564 @default.
- W1972027498 cites W2063358625 @default.
- W1972027498 cites W2077229141 @default.
- W1972027498 cites W2093274912 @default.
- W1972027498 cites W2102863780 @default.
- W1972027498 cites W2104938317 @default.
- W1972027498 cites W2114445980 @default.
- W1972027498 cites W2115449275 @default.
- W1972027498 cites W2120338109 @default.
- W1972027498 cites W2120778027 @default.
- W1972027498 cites W2143930443 @default.
- W1972027498 cites W2147785884 @default.
- W1972027498 cites W2161412749 @default.
- W1972027498 cites W2412034936 @default.
- W1972027498 doi "https://doi.org/10.1016/j.metabol.2011.11.009" @default.
- W1972027498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22209095" @default.
- W1972027498 hasPublicationYear "2012" @default.
- W1972027498 type Work @default.
- W1972027498 sameAs 1972027498 @default.
- W1972027498 citedByCount "59" @default.
- W1972027498 countsByYear W19720274982012 @default.
- W1972027498 countsByYear W19720274982013 @default.
- W1972027498 countsByYear W19720274982014 @default.
- W1972027498 countsByYear W19720274982015 @default.
- W1972027498 countsByYear W19720274982016 @default.
- W1972027498 countsByYear W19720274982017 @default.
- W1972027498 countsByYear W19720274982018 @default.
- W1972027498 countsByYear W19720274982019 @default.
- W1972027498 countsByYear W19720274982020 @default.
- W1972027498 countsByYear W19720274982021 @default.
- W1972027498 countsByYear W19720274982022 @default.
- W1972027498 countsByYear W19720274982023 @default.
- W1972027498 crossrefType "journal-article" @default.
- W1972027498 hasAuthorship W1972027498A5010029482 @default.
- W1972027498 hasAuthorship W1972027498A5020357107 @default.
- W1972027498 hasAuthorship W1972027498A5027726446 @default.
- W1972027498 hasAuthorship W1972027498A5040743356 @default.
- W1972027498 hasAuthorship W1972027498A5040790993 @default.
- W1972027498 hasAuthorship W1972027498A5052423373 @default.
- W1972027498 hasAuthorship W1972027498A5053378507 @default.
- W1972027498 hasAuthorship W1972027498A5063050485 @default.
- W1972027498 hasAuthorship W1972027498A5066470222 @default.
- W1972027498 hasAuthorship W1972027498A5082493161 @default.
- W1972027498 hasAuthorship W1972027498A5087611764 @default.
- W1972027498 hasConcept C126322002 @default.
- W1972027498 hasConcept C134018914 @default.
- W1972027498 hasConcept C150903083 @default.
- W1972027498 hasConcept C185592680 @default.
- W1972027498 hasConcept C207001950 @default.
- W1972027498 hasConcept C2776731943 @default.
- W1972027498 hasConcept C2777477808 @default.
- W1972027498 hasConcept C2778435403 @default.
- W1972027498 hasConcept C31532488 @default.
- W1972027498 hasConcept C55493867 @default.
- W1972027498 hasConcept C555293320 @default.
- W1972027498 hasConcept C62231903 @default.
- W1972027498 hasConcept C71924100 @default.
- W1972027498 hasConcept C82714985 @default.
- W1972027498 hasConcept C86803240 @default.
- W1972027498 hasConceptScore W1972027498C126322002 @default.
- W1972027498 hasConceptScore W1972027498C134018914 @default.
- W1972027498 hasConceptScore W1972027498C150903083 @default.
- W1972027498 hasConceptScore W1972027498C185592680 @default.
- W1972027498 hasConceptScore W1972027498C207001950 @default.
- W1972027498 hasConceptScore W1972027498C2776731943 @default.
- W1972027498 hasConceptScore W1972027498C2777477808 @default.
- W1972027498 hasConceptScore W1972027498C2778435403 @default.