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- W1972030881 abstract "BackgroundThe autosomal recessive chromosomal instability disorder Nijmegen breakage syndrome (NBS) is associated with increased risk of lymphoid malignancies and other cancers. Cells from NBS patients contain many double-stranded DNA breaks. More than 90% of NBS patients are homozygous for a founder mutation, 657del5, in the NBN gene. We investigated the 657del5 carrier status of cancer patients among blood relatives (i.e., first-, through fourth-degree relatives) of NBS patients in the Czech Republic and Slovakia to test the hypothesis that NBN heterozygotes have an increased cancer risk." @default.
- W1972030881 created "2016-06-24" @default.
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- W1972030881 date "2007-12-11" @default.
- W1972030881 modified "2023-10-01" @default.
- W1972030881 title "Cancer Risk of Heterozygotes With the NBN Founder Mutation" @default.
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- W1972030881 doi "https://doi.org/10.1093/jnci/djm251" @default.
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