FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972033253> ?p ?o ?g. }

• W1972033253 abstract "Abstract Ribozymes are RNA molecules that act enzymatically to cleave other RNA molecules. The cleavage reaction requires the binding of ribozyme to specific sites on the target RNA through (mostly) Watson-Crick base-pairing interactions. Association of ribozyme with target completes a three-dimensional ribozyme/target complex which results in cleavage of the target RNA. We are employing both computational and experimental approaches to identify sites on target RNA molecules that are open to ribozyme attack and to determine which ribozymes are most active against those sites. Two types of computational technologies are available for aiding in the identification of target sites and design of active ribozymes. First, DNA/RNA sequence analysis software is employed to identify sequence motifs necessary for ribozyme cleavage and to look for sequence conservation between different sources of the target organism so that ribozymes with the broadest possible target range can be designed. Second, RNA folding algorithms are employed to predict the secondary structure of both ribozyme and target RNA in an attempt to identify combinations of ribozyme and target site that will successfully associate prior to ribozyme cleavage. The RNA folding algorithms utilize a set of thermodynamic parameters obtained from measurements on short RNA duplexes; while these rules give reasonable predictions of secondary structure for a small set of highly structured RNAs, they remain largely untested for predicting the structure of messenger RNAs. This paper outlines the current status of designing ribozymes that fold correctly and of locating target sites that are sufficiently unfolded to allow ribozyme cleavage." @default.
• W1972033253 created "2016-06-24" @default.
• W1972033253 creator A5009999227 @default.
• W1972033253 creator A5036883896 @default.
• W1972033253 creator A5049215519 @default.
• W1972033253 date "1994-07-01" @default.
• W1972033253 modified "2023-09-27" @default.
• W1972033253 title "Application of computational technologies to ribozyme biotechnology products" @default.
• W1972033253 cites W102448331 @default.
• W1972033253 cites W1486369891 @default.
• W1972033253 cites W1490558618 @default.
• W1972033253 cites W1492919412 @default.
• W1972033253 cites W1513063835 @default.
• W1972033253 cites W1526127001 @default.
• W1972033253 cites W1530482967 @default.
• W1972033253 cites W1573686430 @default.
• W1972033253 cites W1674554014 @default.
• W1972033253 cites W1971402940 @default.
• W1972033253 cites W1981472560 @default.
• W1972033253 cites W1989794771 @default.
• W1972033253 cites W1990059782 @default.
• W1972033253 cites W1991938283 @default.
• W1972033253 cites W1995403172 @default.
• W1972033253 cites W1998358440 @default.
• W1972033253 cites W2000191287 @default.
• W1972033253 cites W2002048308 @default.
• W1972033253 cites W2004545420 @default.
• W1972033253 cites W2017313617 @default.
• W1972033253 cites W2018802169 @default.
• W1972033253 cites W2020588168 @default.
• W1972033253 cites W2022561737 @default.
• W1972033253 cites W2023498755 @default.
• W1972033253 cites W2025763720 @default.
• W1972033253 cites W2026358434 @default.
• W1972033253 cites W2035783320 @default.
• W1972033253 cites W2046146519 @default.
• W1972033253 cites W2056975726 @default.
• W1972033253 cites W2057388609 @default.
• W1972033253 cites W2072737163 @default.
• W1972033253 cites W2087862352 @default.
• W1972033253 cites W2088259814 @default.
• W1972033253 cites W2094274064 @default.
• W1972033253 cites W2095253740 @default.
• W1972033253 cites W2105046056 @default.
• W1972033253 cites W2108135447 @default.
• W1972033253 cites W2113368761 @default.
• W1972033253 cites W2120713755 @default.
• W1972033253 cites W2125498037 @default.
• W1972033253 cites W2143151924 @default.
• W1972033253 cites W2151538750 @default.
• W1972033253 cites W2155373804 @default.
• W1972033253 cites W2158626412 @default.
• W1972033253 cites W2163414819 @default.
• W1972033253 cites W2180891129 @default.
• W1972033253 cites W2166824799 @default.
• W1972033253 doi "https://doi.org/10.1016/s0022-2860(10)80037-7" @default.
• W1972033253 hasPublicationYear "1994" @default.
• W1972033253 type Work @default.
• W1972033253 sameAs 1972033253 @default.
• W1972033253 citedByCount "10" @default.
• W1972033253 crossrefType "journal-article" @default.
• W1972033253 hasAuthorship W1972033253A5009999227 @default.
• W1972033253 hasAuthorship W1972033253A5036883896 @default.
• W1972033253 hasAuthorship W1972033253A5049215519 @default.
• W1972033253 hasConcept C104317684 @default.
• W1972033253 hasConcept C105130999 @default.
• W1972033253 hasConcept C107745601 @default.
• W1972033253 hasConcept C126142528 @default.
• W1972033253 hasConcept C1342335 @default.
• W1972033253 hasConcept C151730666 @default.
• W1972033253 hasConcept C175156509 @default.
• W1972033253 hasConcept C185581394 @default.
• W1972033253 hasConcept C2779792011 @default.
• W1972033253 hasConcept C30951146 @default.
• W1972033253 hasConcept C43369102 @default.
• W1972033253 hasConcept C54355233 @default.
• W1972033253 hasConcept C552990157 @default.
• W1972033253 hasConcept C66144319 @default.
• W1972033253 hasConcept C67705224 @default.
• W1972033253 hasConcept C70721500 @default.
• W1972033253 hasConcept C76346623 @default.
• W1972033253 hasConcept C86803240 @default.
• W1972033253 hasConceptScore W1972033253C104317684 @default.
• W1972033253 hasConceptScore W1972033253C105130999 @default.
• W1972033253 hasConceptScore W1972033253C107745601 @default.
• W1972033253 hasConceptScore W1972033253C126142528 @default.
• W1972033253 hasConceptScore W1972033253C1342335 @default.
• W1972033253 hasConceptScore W1972033253C151730666 @default.
• W1972033253 hasConceptScore W1972033253C175156509 @default.
• W1972033253 hasConceptScore W1972033253C185581394 @default.
• W1972033253 hasConceptScore W1972033253C2779792011 @default.
• W1972033253 hasConceptScore W1972033253C30951146 @default.
• W1972033253 hasConceptScore W1972033253C43369102 @default.
• W1972033253 hasConceptScore W1972033253C54355233 @default.
• W1972033253 hasConceptScore W1972033253C552990157 @default.
• W1972033253 hasConceptScore W1972033253C66144319 @default.
• W1972033253 hasConceptScore W1972033253C67705224 @default.
• W1972033253 hasConceptScore W1972033253C70721500 @default.
• W1972033253 hasConceptScore W1972033253C76346623 @default.
• W1972033253 hasConceptScore W1972033253C86803240 @default.

• next