FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972033972> ?p ?o ?g. }

• W1972033972 endingPage "147" @default.
• W1972033972 startingPage "140" @default.
• W1972033972 abstract "HLA-B27 is highly linked with a group of human diseases called spondyloarthropathies (SpA). Many of these disorders begin after an infection with an enterobacteria. The symptoms seen in patients with spondyloarthropathies are inflammatory pain in the spine and asymmetrical arthritis of lower limbs. Additional symptoms related to SpA include inflammation in the eyes, bowel, and skin. The autoantigen(s) in SpA are not known. Proteins such as collagen and proteoglycans have been thought to be potent autoantigens in arthritidis including B27-associated human diseases. Type II collagen is a common denominator among eyes and joints, affected tissues in B27-linked diseases. Moreover, a few reports indicated CII specific T cells and antibodies in patients with spondyloarthropathies. We and others have previously described development of spontaneous arthritis and nail disease in HLA-B27 transgenic animals. To determine whether CII may be a target antigen in the B27-linked diseases, B27 + m beta 2 m% (HLA-B27) transgenic mice lacking mouse beta 2m with and without human beta 2m) mice were immunized with type II collagen inside the barrier facility. Male HLA-B27 transgenic mice developed collagen-induced arthritis compared to transgene negative littermates or female counterparts. There was no difference in the incidence of arthritis in HLA-B27 transgenic mice with and without human beta 2m. Our data suggest that beta 2m free heavy chain of HLA-B27 may present soluble antigens such as type II collagen to trigger specific T cells contributing in the development of arthritis. Our data also suggest that CII may be a potential target antigen in the cartilage during the disease process." @default.
• W1972033972 created "2016-06-24" @default.
• W1972033972 creator A5031002502 @default.
• W1972033972 creator A5032970634 @default.
• W1972033972 creator A5040789268 @default.
• W1972033972 creator A5041731742 @default.
• W1972033972 creator A5045758352 @default.
• W1972033972 date "2000-02-01" @default.
• W1972033972 modified "2023-09-27" @default.
• W1972033972 title "HLA-B27 transgenic mice are susceptible to collagen-induced arthritis: type II collagen as a potential target in human disease" @default.
• W1972033972 cites W1508263122 @default.
• W1972033972 cites W1589282389 @default.
• W1972033972 cites W1600814946 @default.
• W1972033972 cites W1608301964 @default.
• W1972033972 cites W1980990177 @default.
• W1972033972 cites W1988829774 @default.
• W1972033972 cites W1993234699 @default.
• W1972033972 cites W1995083686 @default.
• W1972033972 cites W2009802108 @default.
• W1972033972 cites W2022911085 @default.
• W1972033972 cites W2034298592 @default.
• W1972033972 cites W2040113209 @default.
• W1972033972 cites W2040549990 @default.
• W1972033972 cites W2040937120 @default.
• W1972033972 cites W2045155895 @default.
• W1972033972 cites W2049476767 @default.
• W1972033972 cites W2067001395 @default.
• W1972033972 cites W2067249142 @default.
• W1972033972 cites W2071630485 @default.
• W1972033972 cites W2072882365 @default.
• W1972033972 cites W2077103228 @default.
• W1972033972 cites W2079923627 @default.
• W1972033972 cites W2103233025 @default.
• W1972033972 cites W2105296887 @default.
• W1972033972 cites W2108617609 @default.
• W1972033972 cites W2111949223 @default.
• W1972033972 cites W2117267944 @default.
• W1972033972 cites W2117901432 @default.
• W1972033972 cites W2120229668 @default.
• W1972033972 cites W2126227560 @default.
• W1972033972 cites W2126297588 @default.
• W1972033972 cites W2137109050 @default.
• W1972033972 cites W2137156643 @default.
• W1972033972 cites W2156690580 @default.
• W1972033972 cites W2163535620 @default.
• W1972033972 doi "https://doi.org/10.1016/s0198-8859(99)00148-2" @default.
• W1972033972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10717806" @default.
• W1972033972 hasPublicationYear "2000" @default.
• W1972033972 type Work @default.
• W1972033972 sameAs 1972033972 @default.
• W1972033972 citedByCount "8" @default.
• W1972033972 countsByYear W19720339722022 @default.
• W1972033972 crossrefType "journal-article" @default.
• W1972033972 hasAuthorship W1972033972A5031002502 @default.
• W1972033972 hasAuthorship W1972033972A5032970634 @default.
• W1972033972 hasAuthorship W1972033972A5040789268 @default.
• W1972033972 hasAuthorship W1972033972A5041731742 @default.
• W1972033972 hasAuthorship W1972033972A5045758352 @default.
• W1972033972 hasConcept C102230213 @default.
• W1972033972 hasConcept C104317684 @default.
• W1972033972 hasConcept C141035611 @default.
• W1972033972 hasConcept C142724271 @default.
• W1972033972 hasConcept C147483822 @default.
• W1972033972 hasConcept C188280979 @default.
• W1972033972 hasConcept C199360897 @default.
• W1972033972 hasConcept C203014093 @default.
• W1972033972 hasConcept C2776174256 @default.
• W1972033972 hasConcept C2777077863 @default.
• W1972033972 hasConcept C2777365958 @default.
• W1972033972 hasConcept C2778091532 @default.
• W1972033972 hasConcept C2778260677 @default.
• W1972033972 hasConcept C2779134260 @default.
• W1972033972 hasConcept C2781013607 @default.
• W1972033972 hasConcept C41008148 @default.
• W1972033972 hasConcept C54355233 @default.
• W1972033972 hasConcept C71924100 @default.
• W1972033972 hasConcept C86803240 @default.
• W1972033972 hasConceptScore W1972033972C102230213 @default.
• W1972033972 hasConceptScore W1972033972C104317684 @default.
• W1972033972 hasConceptScore W1972033972C141035611 @default.
• W1972033972 hasConceptScore W1972033972C142724271 @default.
• W1972033972 hasConceptScore W1972033972C147483822 @default.
• W1972033972 hasConceptScore W1972033972C188280979 @default.
• W1972033972 hasConceptScore W1972033972C199360897 @default.
• W1972033972 hasConceptScore W1972033972C203014093 @default.
• W1972033972 hasConceptScore W1972033972C2776174256 @default.
• W1972033972 hasConceptScore W1972033972C2777077863 @default.
• W1972033972 hasConceptScore W1972033972C2777365958 @default.
• W1972033972 hasConceptScore W1972033972C2778091532 @default.
• W1972033972 hasConceptScore W1972033972C2778260677 @default.
• W1972033972 hasConceptScore W1972033972C2779134260 @default.
• W1972033972 hasConceptScore W1972033972C2781013607 @default.
• W1972033972 hasConceptScore W1972033972C41008148 @default.
• W1972033972 hasConceptScore W1972033972C54355233 @default.
• W1972033972 hasConceptScore W1972033972C71924100 @default.
• W1972033972 hasConceptScore W1972033972C86803240 @default.
• W1972033972 hasIssue "2" @default.
• W1972033972 hasLocation W19720339721 @default.

• next