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- W1972035961 abstract "The effect of thiol reagents on the specific binding of the atypical neuroleptic, sulpiride, to rat striatal membranes are examined. Pretreatment of membranes with N-ethylmaleimide (NEM), but not with iodoacetamide or dithiothreitol (DTT), diminishes [3H]sulpiride binding. The effect is dependent on time, temperature, and the concentration of NEM. The reaction proceeds with pseudo-first-order rate kinetics, indicating the involvement of a single essential SH group in the binding of [3H]sulpiride to striatal membranes sites. Both sodium and sulpiride, but not nucleotides, protect the [3H]sulpiride sites from NEM inactivation in a dose-dependent fashion. As sodium is essential for [3H]sulpiride binding it is possible that in the presence of sodium and sulpiride a conformational change takes place that makes the essential SH group less accessible to alkylation." @default.
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- W1972035961 date "1982-05-01" @default.
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- W1972035961 title "Influence of Sodium and Sulphydryl Groups on [<sup>3</sup>H]Sulpiride Binding Sites in Rat Striatal Membranes" @default.
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- W1972035961 doi "https://doi.org/10.1111/j.1471-4159.1982.tb07926.x" @default.
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