FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972044372> ?p ?o ?g. }

• W1972044372 endingPage "2188" @default.
• W1972044372 startingPage "2176" @default.
• W1972044372 abstract "Abstract Novel cardiovascular replacements are being developed by using degradable synthetic scaffolds, which function as a temporary guide to induce neotissue formation directly in situ . Priming of such scaffolds with fast‐releasing monocyte chemoattractant protein‐1 ( MCP ‐1) was shown to improve the formation of functional neoarteries in rats. However, the underlying mechanism has not been clarified. Therefore, the goal of this study was to investigate the effect of a burst‐release of MCP ‐1 from a synthetic scaffold on the local recruitment of circulating leucocytes under haemodynamic conditions. Herein, we hypothesized that MCP ‐1 initiates a desired healing cascade by recruiting favourable monocyte subpopulations into the implanted scaffold. Electrospun poly(ε‐caprolactone) scaffolds were loaded with fibrin gel containing various doses of MCP ‐1 and exposed to a suspension of human peripheral blood mononuclear cells in static or dynamic conditions. In standard migration assay, a dose‐dependent migration of specific CD 14 + monocyte subsets was observed, as measured by flow cytometry. In conditions of pulsatile flow, on the other hand, a marked increase in immediate monocyte recruitment was observed, but without evident selectivity in monocyte subsets. This suggests that the selectivity was dependent on the release kinetics of the MCP ‐1, as it was overruled by the effect of shear stress after the initial burst‐release. Furthermore, these findings demonstrate that local recruitment of specific MCP ‐1‐responsive monocytes is not the fundamental principle behind the improved neotissue formation observed in long‐term in vivo studies, and mobilization of MCP ‐1‐responsive cells from the bone marrow into the bloodstream is suggested to play a predominant role in vivo ." @default.
• W1972044372 created "2016-06-24" @default.
• W1972044372 creator A5023800488 @default.
• W1972044372 creator A5032481936 @default.
• W1972044372 creator A5037238098 @default.
• W1972044372 creator A5044939299 @default.
• W1972044372 creator A5067670970 @default.
• W1972044372 date "2014-08-08" @default.
• W1972044372 modified "2023-10-03" @default.
• W1972044372 title "Shear flow affects selective monocyte recruitment into <scp>MCP</scp> ‐1‐loaded scaffolds" @default.
• W1972044372 cites W138407706 @default.
• W1972044372 cites W1493858061 @default.
• W1972044372 cites W1550325400 @default.
• W1972044372 cites W1574813722 @default.
• W1972044372 cites W1579795923 @default.
• W1972044372 cites W1965859404 @default.
• W1972044372 cites W1966100182 @default.
• W1972044372 cites W1968100342 @default.
• W1972044372 cites W1972930270 @default.
• W1972044372 cites W1973404873 @default.
• W1972044372 cites W1984378291 @default.
• W1972044372 cites W1995295523 @default.
• W1972044372 cites W1997986066 @default.
• W1972044372 cites W2003571290 @default.
• W1972044372 cites W2010239439 @default.
• W1972044372 cites W2010472544 @default.
• W1972044372 cites W2014593879 @default.
• W1972044372 cites W2015141049 @default.
• W1972044372 cites W2024572142 @default.
• W1972044372 cites W2028867424 @default.
• W1972044372 cites W2030198326 @default.
• W1972044372 cites W2035809865 @default.
• W1972044372 cites W2037428326 @default.
• W1972044372 cites W2038295450 @default.
• W1972044372 cites W2041016801 @default.
• W1972044372 cites W2042233722 @default.
• W1972044372 cites W2044967972 @default.
• W1972044372 cites W2046208657 @default.
• W1972044372 cites W2053727283 @default.
• W1972044372 cites W2054485300 @default.
• W1972044372 cites W2060820658 @default.
• W1972044372 cites W2065145765 @default.
• W1972044372 cites W2065318089 @default.
• W1972044372 cites W2065624229 @default.
• W1972044372 cites W2065678169 @default.
• W1972044372 cites W2065940774 @default.
• W1972044372 cites W2069580663 @default.
• W1972044372 cites W2070438219 @default.
• W1972044372 cites W2073889644 @default.
• W1972044372 cites W2075702611 @default.
• W1972044372 cites W2079034889 @default.
• W1972044372 cites W2082013410 @default.
• W1972044372 cites W2084017822 @default.
• W1972044372 cites W2085099489 @default.
• W1972044372 cites W2085581142 @default.
• W1972044372 cites W2101444839 @default.
• W1972044372 cites W2101955404 @default.
• W1972044372 cites W2105659895 @default.
• W1972044372 cites W2115147216 @default.
• W1972044372 cites W2125711219 @default.
• W1972044372 cites W2127130537 @default.
• W1972044372 cites W2130647266 @default.
• W1972044372 cites W2135703618 @default.
• W1972044372 cites W2143318553 @default.
• W1972044372 cites W2147481524 @default.
• W1972044372 cites W2155444336 @default.
• W1972044372 cites W2156013098 @default.
• W1972044372 cites W2158550197 @default.
• W1972044372 cites W4248565951 @default.
• W1972044372 doi "https://doi.org/10.1111/jcmm.12330" @default.
• W1972044372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224552" @default.
• W1972044372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25103256" @default.
• W1972044372 hasPublicationYear "2014" @default.
• W1972044372 type Work @default.
• W1972044372 sameAs 1972044372 @default.
• W1972044372 citedByCount "34" @default.
• W1972044372 countsByYear W19720443722014 @default.
• W1972044372 countsByYear W19720443722015 @default.
• W1972044372 countsByYear W19720443722016 @default.
• W1972044372 countsByYear W19720443722017 @default.
• W1972044372 countsByYear W19720443722018 @default.
• W1972044372 countsByYear W19720443722019 @default.
• W1972044372 countsByYear W19720443722020 @default.
• W1972044372 countsByYear W19720443722021 @default.
• W1972044372 countsByYear W19720443722022 @default.
• W1972044372 countsByYear W19720443722023 @default.
• W1972044372 crossrefType "journal-article" @default.
• W1972044372 hasAuthorship W1972044372A5023800488 @default.
• W1972044372 hasAuthorship W1972044372A5032481936 @default.
• W1972044372 hasAuthorship W1972044372A5037238098 @default.
• W1972044372 hasAuthorship W1972044372A5044939299 @default.
• W1972044372 hasAuthorship W1972044372A5067670970 @default.
• W1972044372 hasBestOaLocation W19720443721 @default.
• W1972044372 hasConcept C12554922 @default.
• W1972044372 hasConcept C134018914 @default.
• W1972044372 hasConcept C136229726 @default.
• W1972044372 hasConcept C137061746 @default.
• W1972044372 hasConcept C137738243 @default.

• next