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• W1972045844 startingPage "1906" @default.
• W1972045844 abstract "Cytotoxicity-guided phytochemical investigation of a methanolic extract of Croton tonkinensis afforded two new kaurane diterpenoids (1, 2) and 10 known ent-kaurane-type diterpenoids (3−12). The structures of 1 and 2 were based on analysis of spectroscopic and mass spectral data. Compounds 3−12 were identified by comparison of their spectroscopic and physical data with those reported in the literature. Selected compounds from this plant were examined for cytotoxic and anti-inflammatory activities. Compounds 4 and 9 showed the highest cytotoxic activity against the tested tumor cell lines. Compounds 3, 4, 6, 8, 9, and 11 had IC50 values less than 5 µM and were more potent than the nonspecific NOS inhibitor L-NAME in inhibiting LPS-induced NO production." @default.
• W1972045844 created "2016-06-24" @default.
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• W1972045844 date "2007-12-01" @default.
• W1972045844 modified "2023-10-18" @default.
• W1972045844 title "Crotonkinins A and B and Related Diterpenoids from <i>Croton tonkinensis</i> as Anti-inflammatory and Antitumor Agents" @default.
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• W1972045844 doi "https://doi.org/10.1021/np070383f" @default.
• W1972045844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18161942" @default.
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