Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972056987> ?p ?o ?g. }
- W1972056987 endingPage "510" @default.
- W1972056987 startingPage "501" @default.
- W1972056987 abstract "The behavioral and biochemical effects of ethanol in man and animals have been investigated for a long time. A role of catecholamines in the central stimulatory action and during withdrawal has been envisaged, but more recent observations have revealed the involvement of inhibitory synaptic transmitter, GABA, in the actions of ethanol. Ethanol-induced motor incoordination, hypnosedation, antianxiety, and anticonvulsant actions are reported to be GABA-mediated. Involvement of the GABA system has been implicated in ethanol withdrawal-induced seizures in animals. More direct evidences using Cl- influx studies in synaptoneurosomes and spinal neuronal culture studies confirm such a mode of action of ethanol, probably influencing the chloride channel modulation at the GABA-benzodiazepine receptor ionophore complex. RO15-4513 (ethyl-8-azido-5,6-dihydro-5-methyl-6-Oxo-4H-imidazo [1,5-alpha], [1,4] benzodiazepine-3-carboxylate), a novel imidazobenzodiazepine, an analogue of the classical benzodiazepine antagonist is reported to possess alcohol antagonistic properties. RO15-4513 reverses both the behavioral and biochemical effects of ethanol, including the action of GABA-induced Cl- fluxes. But its potential clinical application may be restricted due to its inverse agonistic property. The present review focuses on the GABA-linked behavioral and biochemical actions of ethanol and discusses the potential of RO15-4513 as an alcohol antagonist." @default.
- W1972056987 created "2016-06-24" @default.
- W1972056987 creator A5045323788 @default.
- W1972056987 creator A5062309116 @default.
- W1972056987 date "1988-06-01" @default.
- W1972056987 modified "2023-10-13" @default.
- W1972056987 title "Molecular interactions of ethanol with GABAergic system and potential of RO15–4513 as an ethanol antagonist" @default.
- W1972056987 cites W1751807524 @default.
- W1972056987 cites W1970694478 @default.
- W1972056987 cites W1972191901 @default.
- W1972056987 cites W1974780959 @default.
- W1972056987 cites W1975044780 @default.
- W1972056987 cites W1976130361 @default.
- W1972056987 cites W1982839956 @default.
- W1972056987 cites W1983493352 @default.
- W1972056987 cites W1984989359 @default.
- W1972056987 cites W1988478202 @default.
- W1972056987 cites W1988890863 @default.
- W1972056987 cites W1990426263 @default.
- W1972056987 cites W1993323105 @default.
- W1972056987 cites W1994390079 @default.
- W1972056987 cites W1996029571 @default.
- W1972056987 cites W1999539557 @default.
- W1972056987 cites W2000872351 @default.
- W1972056987 cites W2002660252 @default.
- W1972056987 cites W2003916405 @default.
- W1972056987 cites W2006232903 @default.
- W1972056987 cites W2006464297 @default.
- W1972056987 cites W2012249011 @default.
- W1972056987 cites W2012692752 @default.
- W1972056987 cites W2014444966 @default.
- W1972056987 cites W2014459508 @default.
- W1972056987 cites W2015661750 @default.
- W1972056987 cites W2016800632 @default.
- W1972056987 cites W2017304548 @default.
- W1972056987 cites W2017509694 @default.
- W1972056987 cites W2017999254 @default.
- W1972056987 cites W2018454209 @default.
- W1972056987 cites W2018785988 @default.
- W1972056987 cites W2019989262 @default.
- W1972056987 cites W2021201177 @default.
- W1972056987 cites W2022027469 @default.
- W1972056987 cites W2023642970 @default.
- W1972056987 cites W2023716188 @default.
- W1972056987 cites W2023878197 @default.
- W1972056987 cites W2023935196 @default.
- W1972056987 cites W2024401312 @default.
- W1972056987 cites W2025456391 @default.
- W1972056987 cites W2026790649 @default.
- W1972056987 cites W2028650350 @default.
- W1972056987 cites W2030213733 @default.
- W1972056987 cites W2030765121 @default.
- W1972056987 cites W2031392890 @default.
- W1972056987 cites W2032302905 @default.
- W1972056987 cites W2037128128 @default.
- W1972056987 cites W2038504218 @default.
- W1972056987 cites W2043699807 @default.
- W1972056987 cites W2046423550 @default.
- W1972056987 cites W2046838480 @default.
- W1972056987 cites W2048666985 @default.
- W1972056987 cites W2050600804 @default.
- W1972056987 cites W2053703922 @default.
- W1972056987 cites W2054881801 @default.
- W1972056987 cites W2055872879 @default.
- W1972056987 cites W2059146457 @default.
- W1972056987 cites W2060497494 @default.
- W1972056987 cites W2065798695 @default.
- W1972056987 cites W2067547196 @default.
- W1972056987 cites W2069996340 @default.
- W1972056987 cites W2072148375 @default.
- W1972056987 cites W2072157206 @default.
- W1972056987 cites W2073541800 @default.
- W1972056987 cites W2074232859 @default.
- W1972056987 cites W2074354560 @default.
- W1972056987 cites W2075258026 @default.
- W1972056987 cites W2076283948 @default.
- W1972056987 cites W2076596519 @default.
- W1972056987 cites W2078637676 @default.
- W1972056987 cites W2079794573 @default.
- W1972056987 cites W2085249008 @default.
- W1972056987 cites W2085362834 @default.
- W1972056987 cites W2086464244 @default.
- W1972056987 cites W2088050052 @default.
- W1972056987 cites W2088670213 @default.
- W1972056987 cites W2091170854 @default.
- W1972056987 cites W2091177371 @default.
- W1972056987 cites W2112080537 @default.
- W1972056987 cites W2117614741 @default.
- W1972056987 cites W2123251864 @default.
- W1972056987 cites W2129553731 @default.
- W1972056987 cites W2129698510 @default.
- W1972056987 cites W2132553461 @default.
- W1972056987 cites W2135378706 @default.
- W1972056987 cites W2144863637 @default.
- W1972056987 cites W2145845873 @default.
- W1972056987 cites W2146350095 @default.
- W1972056987 cites W2148635227 @default.
- W1972056987 cites W2205947437 @default.