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• W1972072854 abstract "Chop and change: Site-directed mutagenesis has been employed to optimize the activity of an engineered pyridoxal phosphate-dependent aldolase and to invert its inherent threo selectivity in the cleavage of D-β-phenylserines. The modification of the active-site residues generates significant retroaldol activity that compares favorably with that of natural enzymes in terms of efficiency and selectivity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700710_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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• W1972072854 date "2007-05-31" @default.
• W1972072854 modified "2023-10-17" @default.
• W1972072854 title "Enhancing Activity and Controlling Stereoselectivity in a Designed PLP-Dependent Aldolase" @default.
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• W1972072854 doi "https://doi.org/10.1002/anie.200700710" @default.
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