Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972074413> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1972074413 endingPage "277" @default.
- W1972074413 startingPage "270" @default.
- W1972074413 abstract "Tetraethylammonium (TEA+) derivatives in which one of the ethyl groups is replaced by a longer chain alkane (C4-C16) were tested for their ability to block the compound action potential (CAP) of frog sciatic nerve. A parabolic relation between chain length and 100 per cent blocking dose was found, suggesting an optimal size of C12 for the inhibitory receptor. Two types of inhibition were observed. Type 1 was an inhibition of the CAP at all frequencies when the nerve was perfused with the TEA+ derivative. Interaction with tetrodotoxin suggests this is a Na+ channel effect. Type 2 was an irreversible (still present after nerve wash) frequency-dependent inhibition that is distinct from and synergistic with Na+ channel blocking local anesthetics. From the kinetics of inhibition onset and transport studies, it is suggested that the ultralong action of the TEA+ derivatives is mediated by binding to a receptor at the internal part of K+ channels." @default.
- W1972074413 created "2016-06-24" @default.
- W1972074413 creator A5000681966 @default.
- W1972074413 creator A5071663862 @default.
- W1972074413 date "1981-04-01" @default.
- W1972074413 modified "2023-09-23" @default.
- W1972074413 title "The Mechanism of Action of Local Anesthesia by Tetraethylammonium Derivatives" @default.
- W1972074413 doi "https://doi.org/10.1097/00000542-198104000-00003" @default.
- W1972074413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6259968" @default.
- W1972074413 hasPublicationYear "1981" @default.
- W1972074413 type Work @default.
- W1972074413 sameAs 1972074413 @default.
- W1972074413 citedByCount "15" @default.
- W1972074413 countsByYear W19720744132014 @default.
- W1972074413 countsByYear W19720744132016 @default.
- W1972074413 crossrefType "journal-article" @default.
- W1972074413 hasAuthorship W1972074413A5000681966 @default.
- W1972074413 hasAuthorship W1972074413A5071663862 @default.
- W1972074413 hasBestOaLocation W19720744131 @default.
- W1972074413 hasConcept C105795698 @default.
- W1972074413 hasConcept C12554922 @default.
- W1972074413 hasConcept C126322002 @default.
- W1972074413 hasConcept C138496976 @default.
- W1972074413 hasConcept C144745244 @default.
- W1972074413 hasConcept C151626666 @default.
- W1972074413 hasConcept C153461711 @default.
- W1972074413 hasConcept C15744967 @default.
- W1972074413 hasConcept C170493617 @default.
- W1972074413 hasConcept C17077164 @default.
- W1972074413 hasConcept C178790620 @default.
- W1972074413 hasConcept C185263204 @default.
- W1972074413 hasConcept C185592680 @default.
- W1972074413 hasConcept C202751555 @default.
- W1972074413 hasConcept C23186085 @default.
- W1972074413 hasConcept C2776120743 @default.
- W1972074413 hasConcept C2776741303 @default.
- W1972074413 hasConcept C2781295685 @default.
- W1972074413 hasConcept C33923547 @default.
- W1972074413 hasConcept C42219234 @default.
- W1972074413 hasConcept C517785266 @default.
- W1972074413 hasConcept C519063684 @default.
- W1972074413 hasConcept C55493867 @default.
- W1972074413 hasConcept C71240020 @default.
- W1972074413 hasConcept C71924100 @default.
- W1972074413 hasConcept C86803240 @default.
- W1972074413 hasConcept C98274493 @default.
- W1972074413 hasConceptScore W1972074413C105795698 @default.
- W1972074413 hasConceptScore W1972074413C12554922 @default.
- W1972074413 hasConceptScore W1972074413C126322002 @default.
- W1972074413 hasConceptScore W1972074413C138496976 @default.
- W1972074413 hasConceptScore W1972074413C144745244 @default.
- W1972074413 hasConceptScore W1972074413C151626666 @default.
- W1972074413 hasConceptScore W1972074413C153461711 @default.
- W1972074413 hasConceptScore W1972074413C15744967 @default.
- W1972074413 hasConceptScore W1972074413C170493617 @default.
- W1972074413 hasConceptScore W1972074413C17077164 @default.
- W1972074413 hasConceptScore W1972074413C178790620 @default.
- W1972074413 hasConceptScore W1972074413C185263204 @default.
- W1972074413 hasConceptScore W1972074413C185592680 @default.
- W1972074413 hasConceptScore W1972074413C202751555 @default.
- W1972074413 hasConceptScore W1972074413C23186085 @default.
- W1972074413 hasConceptScore W1972074413C2776120743 @default.
- W1972074413 hasConceptScore W1972074413C2776741303 @default.
- W1972074413 hasConceptScore W1972074413C2781295685 @default.
- W1972074413 hasConceptScore W1972074413C33923547 @default.
- W1972074413 hasConceptScore W1972074413C42219234 @default.
- W1972074413 hasConceptScore W1972074413C517785266 @default.
- W1972074413 hasConceptScore W1972074413C519063684 @default.
- W1972074413 hasConceptScore W1972074413C55493867 @default.
- W1972074413 hasConceptScore W1972074413C71240020 @default.
- W1972074413 hasConceptScore W1972074413C71924100 @default.
- W1972074413 hasConceptScore W1972074413C86803240 @default.
- W1972074413 hasConceptScore W1972074413C98274493 @default.
- W1972074413 hasIssue "4" @default.
- W1972074413 hasLocation W19720744131 @default.
- W1972074413 hasLocation W19720744132 @default.
- W1972074413 hasOpenAccess W1972074413 @default.
- W1972074413 hasPrimaryLocation W19720744131 @default.
- W1972074413 hasRelatedWork W1972074413 @default.
- W1972074413 hasRelatedWork W1986178615 @default.
- W1972074413 hasRelatedWork W1989114418 @default.
- W1972074413 hasRelatedWork W2004414155 @default.
- W1972074413 hasRelatedWork W2084979309 @default.
- W1972074413 hasRelatedWork W2106127058 @default.
- W1972074413 hasRelatedWork W2164673774 @default.
- W1972074413 hasRelatedWork W2336916859 @default.
- W1972074413 hasRelatedWork W2341230731 @default.
- W1972074413 hasRelatedWork W2399439848 @default.
- W1972074413 hasVolume "54" @default.
- W1972074413 isParatext "false" @default.
- W1972074413 isRetracted "false" @default.
- W1972074413 magId "1972074413" @default.
- W1972074413 workType "article" @default.