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- W1972074721 abstract "<b>Objectives: </b> To investigate the chemopreventive potential and antilipidperoxidative effects of ethanolic root extract of <i> Tephrosia purpurea </i> (Linn.) Pers. (TpEt) on 7,12-dimethylbenz(a)anthracene (DMBA)- induced hamster buccal pouch carcinoma. <br><b> Materials and Methods:</b> Oral squamous cell carcinoma was developed in the buccal pouch of Syrian golden hamsters, by painting with 0.5% DMBA in liquid paraffin, thrice a week, for 14 weeks. The tumor incidence, volume and burden were determined. Oral administration of TpEt at a dose of 300 mg/kg, b.w., to DMBA (on alternate days for 14 weeks)- painted animals significantly prevented the incidence, volume and burden of the tumor. <br><b> Results:</b> TpEt showed potent antilipidperoxidative effect, as well as enhanced the antioxidant status in DMBA- painted animals. <br><b> Conclusion: </b> TpEt has potent chemopreventive efficacy and significant antilipidperoxidative effect, in DMBA-induced oral carcinogenesis. Further studies are needed to isolate and characterize the bioactive principle." @default.
- W1972074721 created "2016-06-24" @default.
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- W1972074721 date "2006-01-01" @default.
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- W1972074721 title "Anticarcinogenic and antilipidperoxidative effects of<i>Tephrosia purpurea</i>(Linn.) Pers. in 7, 12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinoma" @default.
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- W1972074721 doi "https://doi.org/10.4103/0253-7613.25805" @default.
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