FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972076105> ?p ?o ?g. }

• W1972076105 endingPage "89" @default.
• W1972076105 startingPage "83" @default.
• W1972076105 abstract "Dysfunction of the orexin/hypocretin neurotransmitter system leads to the sleep disorder narcolepsy. Narcolepsy is characterized by excessive daytime sleepiness and the occurrence of cataplexy--a sudden loss of muscle tone triggered by emotionally arousing events. Both symptoms can be treated with drugs that act on dopaminergic systems. Here we have investigated the effect of orexins on the firing of dopaminergic and GABAergic neurons of the substantia nigra (SN) in brain slices. Surprisingly, dopaminergic neurons in pars compacta were unaffected by orexins. In contrast, bath application of orexin A (100 nM) or orexin B (5-300 nM) greatly increased the firing rate of GABAergic neurons in pars reticulata. The orexin B-mediated excitation was unaffected by blocking synaptic transmission (using low-Ca2+/high-Mg2+ solution). However, the effect of orexin B was reduced significantly by thapsigargin (1 microM) and inhibitors of protein kinase A. The presence of orexinergic fibres in the SN pars reticulata was demonstrated by immunohistochemical methods with the fibre density increasing in the rostrocaudal direction. The orexin excitation of SN reticulata cells may help to maintain their high firing rate during waking. Furthermore, the absence of orexin effects in narcolepsy may predispose affected individuals to attacks of cataplexy." @default.
• W1972076105 created "2016-06-24" @default.
• W1972076105 creator A5010492806 @default.
• W1972076105 creator A5024000055 @default.
• W1972076105 creator A5026512970 @default.
• W1972076105 creator A5080488472 @default.
• W1972076105 date "2002-03-01" @default.
• W1972076105 modified "2023-10-13" @default.
• W1972076105 title "Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro" @default.
• W1972076105 cites W1485682868 @default.
• W1972076105 cites W1519232679 @default.
• W1972076105 cites W1538619854 @default.
• W1972076105 cites W1627229807 @default.
• W1972076105 cites W1867285585 @default.
• W1972076105 cites W1942962897 @default.
• W1972076105 cites W1959892192 @default.
• W1972076105 cites W1963609767 @default.
• W1972076105 cites W1973729800 @default.
• W1972076105 cites W1978082185 @default.
• W1972076105 cites W1979818746 @default.
• W1972076105 cites W1980468851 @default.
• W1972076105 cites W1983298714 @default.
• W1972076105 cites W1992927499 @default.
• W1972076105 cites W1994915333 @default.
• W1972076105 cites W1998101177 @default.
• W1972076105 cites W2005634803 @default.
• W1972076105 cites W2008870929 @default.
• W1972076105 cites W2013655437 @default.
• W1972076105 cites W2026613561 @default.
• W1972076105 cites W2027740042 @default.
• W1972076105 cites W2028904201 @default.
• W1972076105 cites W2031462960 @default.
• W1972076105 cites W2035662131 @default.
• W1972076105 cites W2037668299 @default.
• W1972076105 cites W2043514528 @default.
• W1972076105 cites W2049088920 @default.
• W1972076105 cites W2056168176 @default.
• W1972076105 cites W2068973973 @default.
• W1972076105 cites W2072154498 @default.
• W1972076105 cites W2089980331 @default.
• W1972076105 cites W2150132984 @default.
• W1972076105 cites W2152211310 @default.
• W1972076105 cites W2169378022 @default.
• W1972076105 doi "https://doi.org/10.1016/s0167-0115(01)00323-8" @default.
• W1972076105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11830281" @default.
• W1972076105 hasPublicationYear "2002" @default.
• W1972076105 type Work @default.
• W1972076105 sameAs 1972076105 @default.
• W1972076105 citedByCount "88" @default.
• W1972076105 countsByYear W19720761052012 @default.
• W1972076105 countsByYear W19720761052013 @default.
• W1972076105 countsByYear W19720761052014 @default.
• W1972076105 countsByYear W19720761052015 @default.
• W1972076105 countsByYear W19720761052016 @default.
• W1972076105 countsByYear W19720761052017 @default.
• W1972076105 countsByYear W19720761052018 @default.
• W1972076105 countsByYear W19720761052019 @default.
• W1972076105 countsByYear W19720761052020 @default.
• W1972076105 countsByYear W19720761052021 @default.
• W1972076105 countsByYear W19720761052022 @default.
• W1972076105 countsByYear W19720761052023 @default.
• W1972076105 crossrefType "journal-article" @default.
• W1972076105 hasAuthorship W1972076105A5010492806 @default.
• W1972076105 hasAuthorship W1972076105A5024000055 @default.
• W1972076105 hasAuthorship W1972076105A5026512970 @default.
• W1972076105 hasAuthorship W1972076105A5080488472 @default.
• W1972076105 hasConcept C118303440 @default.
• W1972076105 hasConcept C126322002 @default.
• W1972076105 hasConcept C134018914 @default.
• W1972076105 hasConcept C137183658 @default.
• W1972076105 hasConcept C16568411 @default.
• W1972076105 hasConcept C169760540 @default.
• W1972076105 hasConcept C170493617 @default.
• W1972076105 hasConcept C17077164 @default.
• W1972076105 hasConcept C185592680 @default.
• W1972076105 hasConcept C2776119998 @default.
• W1972076105 hasConcept C2776773494 @default.
• W1972076105 hasConcept C2777003273 @default.
• W1972076105 hasConcept C2779177108 @default.
• W1972076105 hasConcept C2779494582 @default.
• W1972076105 hasConcept C2779605129 @default.
• W1972076105 hasConcept C2779680196 @default.
• W1972076105 hasConcept C2780714764 @default.
• W1972076105 hasConcept C2780938664 @default.
• W1972076105 hasConcept C513476851 @default.
• W1972076105 hasConcept C71924100 @default.
• W1972076105 hasConcept C86803240 @default.
• W1972076105 hasConceptScore W1972076105C118303440 @default.
• W1972076105 hasConceptScore W1972076105C126322002 @default.
• W1972076105 hasConceptScore W1972076105C134018914 @default.
• W1972076105 hasConceptScore W1972076105C137183658 @default.
• W1972076105 hasConceptScore W1972076105C16568411 @default.
• W1972076105 hasConceptScore W1972076105C169760540 @default.
• W1972076105 hasConceptScore W1972076105C170493617 @default.
• W1972076105 hasConceptScore W1972076105C17077164 @default.
• W1972076105 hasConceptScore W1972076105C185592680 @default.
• W1972076105 hasConceptScore W1972076105C2776119998 @default.
• W1972076105 hasConceptScore W1972076105C2776773494 @default.

• next