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- W1972077846 abstract "To characterize T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis (RR-EAE), we compared myelin oligodendrocyte glycoprotein (MOG)-induced RR-EAE in C57BL/6 (B6) x SJL (F1) mice and chronic-progressive EAE (CP-EAE) in B6 mice at week 8 p.i. when clinical scores were comparable. Although these two strains exhibited similar inflammation/demyelination pattern and MOG-induced T cell responses, RR-EAE mice produced significantly higher levels of anti-MOG IgG1/IgG2a antibodies. Further, lymphocytes of RR-EAE mice proliferated vigorously to the secondary epitope myelin basic protein (MBP) 1-11. These results support a potential involvement of anti-MOG antibodies and epitope spreading in T cell responses in the development of MOG-induced RR-EAE model." @default.
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- W1972077846 date "2004-03-01" @default.
- W1972077846 modified "2023-10-03" @default.
- W1972077846 title "T cell and antibody responses in remitting–relapsing experimental autoimmune encephalomyelitis in (C57BL/6×SJL) F1 mice" @default.
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- W1972077846 doi "https://doi.org/10.1016/j.jneuroim.2003.10.057" @default.
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