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• W1972080978 abstract "Prion protein (PrP) can be considered a pivotal molecule because it interacts with several partners to perform a diverse range of critical biological functions that might differ in embryonic and adult cells. In recent years, there have been major advances in elucidating the putative role of PrP in the basic biology of stem cells in many different systems. Here, we review the evidence indicating that PrP is a key molecule involved in driving different aspects of the potency of embryonic and tissue-specific stem cells in self-perpetuation and differentiation in many cell types. It has been shown that PrP is involved in stem cell self-renewal, controlling pluripotency gene expression, proliferation, and neural and cardiomyocyte differentiation. PrP also has essential roles in distinct processes that regulate tissue-specific stem cell biology in nervous and hematopoietic systems and during muscle regeneration. Results from our own investigations have shown that PrP is able to modulate self-renewal and prolife..." @default.
• W1972080978 created "2016-06-24" @default.
• W1972080978 creator A5011109148 @default.
• W1972080978 creator A5052695090 @default.
• W1972080978 date "2012-04-01" @default.
• W1972080978 modified "2023-09-24" @default.
• W1972080978 title "Prion potency in stem cells biology" @default.
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• W1972080978 doi "https://doi.org/10.4161/pri.19035" @default.
• W1972080978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7082090" @default.
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• W1972080978 hasPublicationYear "2012" @default.
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