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- W1972082685 abstract "The effects of ethylene glycol (EG) ingestion on glucose tolerance, hepatic glycogen metabolism, anerobic glycolysis, pentose phosphate pathway, and Embden-Meyerhof-tricarboxylic acid (EM-TCA) cycle pathway were investigated in male albino rats. EG was administered po at a daily dose of 2 ml/kg for 6 days. The analyses were done on Day 7. An impaired glucose metabolism was seen from diminished glucose tolerance. Hepatic glycogen concentrations were low associated with decreased glycogen synthetase and increased phosphorylase activities. [U-14C]Glucose incorporation into liver glycogen both in vivo and in vitro was decreased. Studies on the incorporation of 14C of [1-14C]- and [6-14C]glucose into respiratory CO2 showed augmentation of the pentose phosphate pathway, while no significant alteration was observed in glucose oxidation through the EM-TCA cycle pathway. Anerobic glycolysis by liver slices was decreased. The increased NADPH made available by the enhanced pentose phosphate pathway activity following EG treatment may suggest possible oxidation of EG through the microsomal ethanol oxidizing system (MEOS) which is NADPH dependent, as well as through the alcohol dehydrogenase system." @default.
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- W1972082685 date "1978-11-01" @default.
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- W1972082685 title "Effect of ethylene glycol toxicity on hepatic carbohydrate metabolism in rats" @default.
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- W1972082685 doi "https://doi.org/10.1016/0041-008x(78)90096-0" @default.
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