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• W1972083077 startingPage "6603" @default.
• W1972083077 abstract "MeCP2, whose methylated DNA-binding domain (MBD) binds preferentially to DNA containing 5Me-CpG relative to linear unmethylated DNA, also binds preferentially, and with similar affinity, to unmethylated four-way DNA junctions through the MBD. The Arg133Cys (R133C) mutation in the MBD, a Rett syndrome mutation that abolishes binding to methylated DNA, leads to only a slight reduction in the affinity of the MBD for four-way junctions, suggesting distinct but partially overlapping modes of binding to junction and methylated DNA. Binding to unmethylated DNA junctions is likely to involve a subset of the interactions that occur with methylated DNA. High-affinity, methylation-independent binding to four-way junctions is consistent with additional roles for MeCP2 in chromatin, beyond recognition of 5Me-CpG." @default.
• W1972083077 created "2016-06-24" @default.
• W1972083077 creator A5087821587 @default.
• W1972083077 date "2005-11-27" @default.
• W1972083077 modified "2023-10-17" @default.
• W1972083077 title "Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain" @default.
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• W1972083077 doi "https://doi.org/10.1093/nar/gki971" @default.
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