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- W1972087146 abstract "The SOD-like activity of the copper(II) complexes of five amino acid (Gly, Ala, Ser, Asn, Glu) dithiocarbamates was determined. The concentration of the complexes that inhibit by 50% (IC50) the reduction of nitroblue tetrazolium by superoxide radical (generated by xanthine oxidase) lies between 1.2 μM (Glu) and 20 μM (Gly). Quantitative structure-activity relationships, QSAR, were established between pIC50 (-log IC50) and the molar refraction values of the amino acid substituents, as well as Cu(I) / Cu(II) oxidation potentials (determined by cyclic voltammetry). The high SOD-like activity of the Glu dithiocarbamate complex is interpreted to be due to its distorted geometry based on EPR spectra and conductimetric titration data." @default.
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- W1972087146 date "1997-06-01" @default.
- W1972087146 modified "2023-10-16" @default.
- W1972087146 title "Determination of SOD-Like activity of Copper(II) complexes with α-Amino acid dithiocarbamates" @default.
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- W1972087146 doi "https://doi.org/10.1016/s0162-0134(96)00175-4" @default.
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